ArticleRSC advances2026
Synthesis of spiro-lactam hydrazones by clay catalysis: toxicity, antioxidant, hypolipidemic and
Mohammed El Mesky, Hicham Zgueni, Ismail Bouadid, Jarin Tasnim, Yassine Rhazi, Md Mehedi Hasan, Mohamed Tanghourte, Adil Qabouche, Mohammed Chalkha, Na'il Saleh and 3 more
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In one paragraphArticle in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
13 authors.
Mohammed El MeskyLaboratory of Materials Engineering for the Environment and Natural Resources, Faculty of Sciences and Techniques, Moulay Ismail University of Meknes B.P 509, Boutalamine 52000 Errachidia Morocco m.elmesky@edu.umi.ac.ma.ORCID https://orcid.org/0000-0002-3089-3693 Hicham ZgueniLaboratory of Materials Engineering for the Environment and Natural Resources, Faculty of Sciences and Techniques, Moulay Ismail University of Meknes B.P 509, Boutalamine 52000 Errachidia Morocco m.elmesky@edu.umi.ac.ma.ORCID https://orcid.org/0009-0004-5349-2130 Yassine RhaziLaboratory of Engineering of Organometallic, Molecular Materials, and Environment (LIMOME), Faculty of Sciences Dhar EL Mahraz, Sidi Mohamed Ben Abdellah University P.O. Box 1796 (Atlas) Fez 30000 Morocco.ORCID https://orcid.org/0000-0001-7245-9468 Md Mehedi HasanDepartment of applied Chemistry and Chemical Engineering, University of Rajshahi Rajshahi Bangladesh.
Mohamed TanghourteLaboratory of Materials Engineering for the Environment and Natural Resources, Faculty of Sciences and Techniques, Moulay Ismail University of Meknes B.P 509, Boutalamine 52000 Errachidia Morocco m.elmesky@edu.umi.ac.ma.ORCID https://orcid.org/0009-0000-5788-7317 Mohammed ChalkhaLaboratory of Materials Engineering for the Environment and Natural Resources, Faculty of Sciences and Techniques, Moulay Ismail University of Meknes B.P 509, Boutalamine 52000 Errachidia Morocco m.elmesky@edu.umi.ac.ma.ORCID https://orcid.org/0000-0002-9400-2183 Driss ChebabeLaboratory of Materials Engineering for the Environment and Natural Resources, Faculty of Sciences and Techniques, Moulay Ismail University of Meknes B.P 509, Boutalamine 52000 Errachidia Morocco m.elmesky@edu.umi.ac.ma.ORCID https://orcid.org/0000-0002-1788-7942 El Houssine MabroukLaboratory of Materials Engineering for the Environment and Natural Resources, Faculty of Sciences and Techniques, Moulay Ismail University of Meknes B.P 509, Boutalamine 52000 Errachidia Morocco m.elmesky@edu.umi.ac.ma.ORCID https://orcid.org/0000-0003-1235-479X Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
The development of sustainable synthesis methodologies for multifunctional bioactive molecules represents a critical challenge in green chemistry. Herein, we report the eco-efficient microwave-assisted synthesis of two novel spiro-lactam hydrazone derivatives (FHHA1, FHHA2) using abundant Moroccan Es-sifa natural clay as a separable and bifunctional heterogeneous catalyst. This three-step protocol achieves 86-87% overall yields in only 36 min, compared to 34-38% in 68 h under conventional heating representing an acceleration factor of 113.
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PMID42095110
PMCPMC13142659
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