Evidence map›Paper›PMID 42095090›Full record

ArticleiScience2026

Neuromuscular junction innervation and motor function are preserved by restoring muscarinic signaling in perisynaptic glia in ALS.

Elsa Tremblay, Danielle Arbour, Joanne Vallée, Roberta Piovesana, Geneviève Vallières, Emine Mechichi, Richard Robitaille

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elsa TremblayUniversité de Montréal, Département de Neurosciences, Montréal, QC, Canada.
Danielle ArbourUniversité de Montréal, Département de Neurosciences, Montréal, QC, Canada.
Joanne ValléeUniversité de Montréal, Faculté de l'apprentissage continu, Montréal, QC, Canada.
Roberta PiovesanaUniversité de Montréal, Département de Neurosciences, Montréal, QC, Canada.
Geneviève VallièresUniversité de Montréal, Département de Neurosciences, Montréal, QC, Canada.
Emine MechichiUniversité de Montréal, Département de Neurosciences, Montréal, QC, Canada.
Richard RobitailleUniversité de Montréal, Département de Neurosciences, Montréal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuromuscular junction (NMJ) denervation is an early pathological event in amyotrophic lateral sclerosis (ALS) causing motor dysfunction and paralysis. Glial cells at the NMJ, perisynaptic Schwann cells (PSCs), ensure a balance between maintenance and repair via muscarinic receptor signaling. However, in ALS mouse models, PSCs show an aberrant muscarinic hyperactivation. We posited that this excessive activation impairs the PSC capacity to support NMJ repair in ALS. Beginning at symptoms onset,

Indexed as

Cell biologyMolecular biologyNeurosciencePhysiology

Identifiers

PMID42095090
PMCPMC13141810

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.