Evidence map›Paper›PMID 42095086›Full record

ArticleiScience2026

Syncytin-a deficiency compromises murine sperm function by suppressing PRL/PGE2 and PI3K/AKT/mTOR pathway.

Qianqian Wang, Zhenwei Wang, Zhenpeng Li, Dongle Liu, Xiaotong Yan, Yan Zhang, Ning Chi, Qiang Bian, Zhankui Zhao, Honglian Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qianqian WangDepartment of Pathophysiology, Shandong Second Medical University, Weifang, Shandong 261053, P.R. China.
Zhenwei WangDepartment of Biochemistry, Jining Medical University, Jining, Shandong 272067, P.R. China.
Zhenpeng LiDepartment of Biochemistry, Jining Medical University, Jining, Shandong 272067, P.R. China.
Dongle LiuDepartment of Biochemistry, Jining Medical University, Jining, Shandong 272067, P.R. China.
Xiaotong YanDepartment of Biochemistry, Jining Medical University, Jining, Shandong 272067, P.R. China.
Yan ZhangDepartment of Biochemistry, Jining Medical University, Jining, Shandong 272067, P.R. China.
Ning ChiDepartment of Biochemistry, Jining Medical University, Jining, Shandong 272067, P.R. China.
Qiang BianDepartment of Pathophysiology, Shandong Second Medical University, Weifang, Shandong 261053, P.R. China.
Zhankui ZhaoDepartment of Urology, Seventh People's Hospital of Shanghai University of TCM, Shanghai 200137, P.R. China.
Honglian YuDepartment of Microbiology and Immunology, Shanghai University of Medicine and Health Sciences, Shanghai 201318, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human endogenous retrovirus W envelope protein syncytin-1 (syncytin-a in mus) can be involved in fetal development and tumorigenesis. The role of syncytin-1 in male infertility has not been identified. In this study, the prostatic epithelial-specific syncytin-a knockout (syna CKO) mouse model was constructed. First, male infertility, abnormal testicular seminiferous tubule, and prostate gland were discovered in syna CKO mice. Then, irregular sperm motility, morphology, and MMAF-associated gene expression (AKAP3, SPAG6) were detected in syna CKO mice. Increased prostaglandin E2 (PGE2) and prolactin (PRL) modulate the lipid metabolism of the testis in syna CKO mice. Syna CKO with inhibitor or activator treatment identified that syna knockout could inhibit the PI3K/AKT/mTOR pathway, Ca

Indexed as

Biological sciencesMale reproductive endocrinology

Identifiers

PMID42095086
PMCPMC13141077

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.