Evidence map›Paper›PMID 42095075›Full record

ArticleiScience2026

Single-cell transcriptomics reveal altered B cell responses and T cell senescence in geriatric non-responders to COVID-19 mRNA vaccination.

Jeeda Ismail, Banumathi Tamilselvan, Michael Rubsamen, Jillian Petrosky, Brian Richardson, Leah Zagore, Oladayo A Oyebanji, Debbie Keresztesy, Michael Payne, Dennis Wilk and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Jeeda IsmailSystems Biology and Bioinformatics Program, Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Banumathi TamilselvanSystems Biology and Bioinformatics Program, Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Michael RubsamenSystems Biology and Bioinformatics Program, Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Jillian PetroskySystems Biology and Bioinformatics Program, Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Brian RichardsonSystems Biology and Bioinformatics Program, Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Leah ZagoreSystems Biology and Bioinformatics Program, Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Oladayo A OyebanjiCase Western Reserve University School of Medicine, Cleveland, OH, USA.
Debbie KeresztesyCase Western Reserve University School of Medicine, Cleveland, OH, USA.
Michael PayneCase Western Reserve University School of Medicine, Cleveland, OH, USA.
Dennis WilkCase Western Reserve University School of Medicine, Cleveland, OH, USA.
Lenore CariasCase Western Reserve University School of Medicine, Cleveland, OH, USA.
Htin AungCase Western Reserve University School of Medicine, Cleveland, OH, USA.
Kerri St DenisRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Maegan SheehanRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Brigid M WilsonLouis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA.
Alejandro B BalazsRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Stefan GravensteinWarren Alpert Medical School, Brown University, Providence, RI, USA.
Christopher L KingCase Western Reserve University School of Medicine, Cleveland, OH, USA.
David H CanadayCase Western Reserve University School of Medicine, Cleveland, OH, USA.
Cheryl M CameronSystems Biology and Bioinformatics Program, Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Mark J CameronSystems Biology and Bioinformatics Program, Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immune response to COVID-19 vaccines is diminished in older individuals. To understand the underlying immunobiology, we analyzed single-cell RNA-seq data from PBMCs of SARS-CoV-2 naive nursing home residents with varying humoral responses following BNT162b2 vaccination and validated via flow cytometry. Responders (R) (>4500 AU/mL anti-spike titers) showed enrichment for naive B cell (

Indexed as

ImmunologyMolecular physiologyTranscriptomics

Identifiers

PMID42095075
PMCPMC13141647

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.