ArticleFrontiers in medicine2026
The predictive accuracy of axial length to corneal curvature radius ratio for myopia in children and adolescents.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To analyze the association of axial length to corneal curvature radius ratio (AL/CR) and other ocular biometric parameters with myopia in children and adolescents. Methods: A cross-sectional study was conducted among children and adolescents aged 6 to 12 years without ocular diseases who attended the optometry clinic of the Yantai Aier Ophthalmology Hospital from February 2022 to February 2024. The visual acuity, ocular biometry, and automatic refraction under cycloplegia were measured. The axial length, corneal curvature radius, and AL/CR were compared across different age groups. Pearson correlation and linear regression were performed to analyze the effects of correlated factors on spherical equivalent. Receiver operating characteristic curves were constructed to evaluate the diagnostic efficacy in detecting myopia. Results: A total of 2,760 eyes (right eye) of 2,760 children and adolescents were included. Both axial length and AL/CR increased with age in children and adolescents aged 6 to 12 years, while spherical equivalent decreased with age. Corneal curvature radius did not exhibit significant changes with age. The correlation coefficients between AL/CR, axial length, and spherical equivalent are -0.865 and -0.747, respectively, whereas axial length shows no significant correlation ( Conclusion: The correlation between AL/CR and spherical equivalent (SE) is stronger than that between AL and SE in children and adolescents. AL/CR can independently reflect dynamic changes in SE during myopia progression, without relying solely on optometric data.
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