ArticlePractical laboratory medicine2026
LC-MS/MS of PEth in whole blood: implementation in routine clinical chemistry.
Article in Practical laboratory medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In clinical practice, assessing alcohol intake can be challenging because patients may under-report or misjudge their consumption, so biomarkers of chronic intake provide valuable additional information. Phosphatidylethanol (PEth) is a group of abnormal phospholipids that are formed in cell membranes only in the presence of ethanol (alcohol). We developed, analytically validated, and clinically implemented a rapid and robust LC-MS/MS-based method for quantifying PEth (16:0/18:1) in whole blood. The method demonstrates a limit of detection (LOD) of 0.01 μM and a limit of quantification (LOQ) of 0.03 μM, with confirmed linearity up to at least 0.8 μM. Validation using reference materials and samples from patients with liver disease and self-reported alcohol intake confirmed its accuracy. Clinical implementation over a two-month period, involving 20 analytical batches, demonstrated inter-assay precision below 15%. Our results support the clinical applicability of PEth use for accurate estimation of alcohol intake in humans.
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