Evidence map›Paper›PMID 42094865›Full record

ArticleJournal of the Endocrine Society2026

Plasma metabolites after 10-weeks of glucose vs fructose-sweetened beverages in subjects with overweight/obesity.

Mélanie Guirette, Danielle E Haslam, Jiantao Ma, Peter J Havel, Kimber L Stanhope, Olga Ilkayeva, Christopher B Newgard, Nicola M McKeown, Mark A Herman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mélanie GuiretteFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA.
Danielle E HaslamChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Jiantao MaFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA.ORCID https://orcid.org/0000-0001-7478-7203
Peter J HavelDepartment of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition, University of California, Davis, Davis, CA 95616, USA.
Kimber L StanhopeDepartment of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition, University of California, Davis, Davis, CA 95616, USA.ORCID https://orcid.org/0000-0002-2474-0914
Olga IlkayevaSarah W. Stedman Nutrition and Metabolism Center & Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27701, USA.
Christopher B NewgardSarah W. Stedman Nutrition and Metabolism Center & Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27701, USA.
Nicola M McKeownPrograms of Nutrition, Department of Health Sciences, Sargent College of Health & Rehabilitation Sciences, Boston University, Boston, MA 02215, USA.
Mark A HermanSection of Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA.ORCID https://orcid.org/0000-0001-6979-103X

Funding

Training Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3M
Proteomic and integrative omic profiles of sugar- and artificially sweetened beverage consumption and changes in type 2 diabetes risk factorsK01DK136968 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI Danielle Haslam · 2023 to 2026
$634k
NCI NIH HHS T32 CA009001NIDDK NIH HHS K01 DK136968
6 · The paper itself

Abstract

To identify metabolites as potential biomarkers of fructose vs glucose consumption and related metabolic changes, we conducted exploratory metabolomic profiling of fasting blood samples from participants in a double-blind, parallel-arm trial involving 31 male and female adults with overweight or obesity, both before and after supplementation with glucose- or fructose-sweetened beverages. Orthogonal Partial Least Square Discriminatory Analysis (OPLS-DA) was used to identify metabolites that could discriminate between the 2 intervention groups. Changes in 16 metabolites (5 of which are branched-chain amino acid catabolic pathway metabolites) and the branched chain keto acid (BCKA) composite score showed nominal (FDR adjusted

Indexed as

BCAA catabolic pathwaybranched-chain amino acidsfructose metabolismmetabolomicssugar-sweetened beverage

Identifiers

PMID42094865
PMCPMC13142796

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.