Evidence map›Paper›PMID 42094864›Full record

ArticleJournal of the Endocrine Society2026

Skeletal muscle mitochondrial bioenergetics in pregnancy: a comparison of in vivo and in vitro outcomes.

Ericka M Biagioni, Polina M Krassovskaia, Gillian Tiralla, Kelsey H Fisher-Wellman, Chien-Te Lin, Abby D Altazan, R Caitlin Hebert, Sripallavi Yendamuri, Maninder Singh, Owen T Carmichael and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ericka M BiagioniDepartment of Kinesiology, East Carolina University, Greenville, NC 27858, USA.
Polina M KrassovskaiaDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Gillian TirallaDepartment of Kinesiology, East Carolina University, Greenville, NC 27858, USA.
Kelsey H Fisher-WellmanDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Chien-Te LinDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Abby D AltazanPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
R Caitlin HebertPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
Sripallavi YendamuriDepartment of Kinesiology, East Carolina University, Greenville, NC 27858, USA.
Maninder SinghPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
Owen T CarmichaelPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
P Darrell NeuferDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Kristen E BoyleDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Leanne M RedmanPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
Nicholas T BroskeyDepartment of Kinesiology, East Carolina University, Greenville, NC 27858, USA.ORCID https://orcid.org/0000-0002-1197-5116

Funding

Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI ROBERT A KESTERSON · 2005 to 2026
$26.5M
Expecting Success: Personalized management of body weight during pregnancyU01DK094418 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI REDMAN, LEANNE MAREE · 2011 to 2015
$2.8M
Determinants of gestational weight gain in obese pregnant womenR01DK099175 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI REDMAN, LEANNE MAREE · 2013 to 2015
$1.8M
Effect of Maternal Exercise in Women with Obesity on Offspring Mesenchymal Stem Cell MetabolismR01DK137945 · NIDDK · EAST CAROLINA UNIVERSITY · PI Nicholas Broskey · 2024 to 2026
$1.5M
NIDDK NIH HHS P30 DK072476NIDDK NIH HHS R01 DK099175NIDDK NIH HHS R01 DK137945NIDDK NIH HHS U01 DK094418
6 · The paper itself

Abstract

Purpose: Exercise-mediated adaptations to mitochondria are well established in nongravid populations; however, the extent to which these adaptations occur during pregnancy remains unclear. Therefore, the objective of this study was to compare skeletal muscle mitochondrial bioenergetics in physically active ( Methods: Groups were matched for age, race, and pregravid body mass index and were studied in the second (T2; weeks 21-25) and third trimester (T3; weeks 31-35). Free-living physical activity was assessed by accelerometry and aerobic fitness by peak oxygen uptake (VO Results: Despite a decline in physical activity across gestation, active women maintained a higher VO Conclusion: These findings suggest that late pregnancy may blunt mitochondrial adaptations to aerobic exercise despite a preservation of cardiovascular fitness. Future studies are needed to determine whether increasing activity throughout gestation can enhance mitochondrial respiration.

Indexed as

exercisemetabolismmitochondriamyotubepregnancy

Identifiers

PMID42094864
PMCPMC13142800

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.