ArticleJournal of inflammation research2026
The Clinical Outcomes of Tocilizumab Usage in Cryptogenic Febrile Infection-Related Epilepsy Syndrome at Both Acute and Chronic Phase: A Retrospective Study.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Tocilizumab in FIRES: From Treatment Timing to Treat-to-Target Use [Letter].Journal of inflammation research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To provide more observational evidence for potential efficacy of tocilizumab (TCZ) in children with cryptogenic febrile infection-related epilepsy syndrome (FIRES) administered during acute and chronic phase. Methods: Data of 22 children with FIRES who received TCZ were collected retrospectively. Patients were categorized into two groups: acute group (TCZ used within 4 weeks post-onset; n = 12) and chronic group (TCZ used beyond 4 weeks post-onset; n = 10). Results: In both groups, patients experienced >50% reduction in seizure frequency, electroencephalogram (EEG) improvements, alleviation on cranial magnetic resonance imaging (MRI), and significantly decreased mRS scores ( Conclusion: TCZ treatment was associated with reduced seizure frequency, improved EEG and MRI findings, decreased reliance on antiseizure medications, and functional improvement as measured by mRS. Initiation of treatment during the acute phase may be associated with a shortened duration of status epilepticus and, compared to chronic-phase intervention, appears to correlate with more favorable long-term outcomes.
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