Evidence map›Paper›PMID 42094695›Full record

ArticleFrontiers in chemistry2026

Genome-wide association study of myopia progression in Chinese adolescents and application of polygenic risk score prediction.

Qinye Liu, Hui Shen, Xinglun Dang, Mike Zhongyu He, Yizhou Wei, Yingyun Shi, Xiaoyu Wei, Fen Chen, Di Han, Chengyong Liu and 2 more

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In one paragraph

Article in Frontiers in chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qinye Liu *Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China.
Hui ShenSuzhou Center for Disease Control and Prevention, Suzhou, China.
Xinglun DangDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Advanced Institute for Life and Health, Southeast University, Nanjing, China.
Mike Zhongyu HeDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Yizhou WeiSchool of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China.
Yingyun ShiDepartment of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China.
Xiaoyu WeiDepartment of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China.
Fen ChenDepartment of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China.
Di HanSuzhou Center for Disease Control and Prevention, Suzhou, China.
Chengyong LiuAffiliated Hospital of Nanjing University of Chinese Medicine, Liyang Branch of Jiangsu Province Hospital of Chinese Medicine, Nanjing, China.
Jia HuSuzhou Center for Disease Control and Prevention, Suzhou, China.
Weina Liu *Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, the prevalence of myopia has sharply increased in East Asia, emerging as a major public health issue. This study aimed to identify genetic risk factors for myopia progression and to develop polygenic risk score (PRS) models to predict myopia progression risk. Genotyping was performed using the Asian Screening Array chip among 294 Chinese adolescents who completed a 2-year follow-up. A two-stage (discovery cohort: N = 176; replication cohort: N = 118) genome-wide association study (GWAS) was subsequently conducted. Functional annotation and MAGMA analysis were performed to confirm biological relevance of the identified loci in the progression of myopia. Based on GWAS results from the discovery cohort and a European population from the United Kingdom Biobank (N = 460,536), we constructed single-ancestry and cross-ancestry PRS models with PRSice-2 and PRS-CSx. We evaluated the predictive performance of these models using the replication cohort. Our meta-analysis identified seven novel suggestive loci associated with myopia progression, including

Indexed as

asian screening array chipChinese adolescentsgenome-wide association studymyopia progressionpolygenic risk score

Identifiers

PMID42094695
PMCPMC13139945

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.