Evidence map›Paper›PMID 42094621›Full record

ReviewHealth science reports2026

Molecular Mechanisms of Resistance and Treatment Efficacy of Delamanid Against

Md Mahmudul Islam, Md Zahid Hasan, Md Touki Tahamid Tusar, Md Yeamin Hossain, Md Motaher Hossain, Md Abdulla Al Jubayed, Md Jubaer-Al-Abedin, Sheikh Soikot, Shanzida Akther, Jahid Bhuyian and 10 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Md Mahmudul IslamDepartment of Genetic Engineering and Biotechnology Daffodil International University Dhaka Bangladesh.
Md Zahid HasanDepartment of Microbiology, Rajshahi Institute of Biosciences Affiliated With University of Rajshahi Rajshahi Bangladesh.
Md Touki Tahamid TusarDepartment of Microbiology and Hygiene Bangladesh Agricultural University Mymensingh Bangladesh.
Md Yeamin HossainDepartment of Fisheries University of Rajshahi Rajshahi Bangladesh.
Md Motaher HossainDepartment of Microbiology, Rajshahi Institute of Biosciences Affiliated With University of Rajshahi Rajshahi Bangladesh.
Md Abdulla Al JubayedDepartment of Microbiology, Rajshahi Institute of Biosciences Affiliated With University of Rajshahi Rajshahi Bangladesh.
Md Jubaer-Al-AbedinDepartment of Microbiology, Rajshahi Institute of Biosciences Affiliated With University of Rajshahi Rajshahi Bangladesh.
Sheikh SoikotDepartment of Pharmacy University of Rajshahi Rajshahi Bangladesh.
Shanzida AktherDepartment of Pharmacy University of Rajshahi Rajshahi Bangladesh.
Jahid BhuyianDepartment of Agriculture, Rajshahi Institute of Biosciences Affiliated With University of Rajshahi Rajshahi Bangladesh.
Hafizur Rahman GaziDepartment of Biotechnology and Genetic Engineering Gopalganj Science and Technology University Gopalganj Bangladesh.
B M Mahmudul HasanDepartment of Food and Nutrition, Barishal Home Economics College Affiliated by University of Dhaka Dhaka Bangladesh.
Md Shofiul AzamDepartment of Food Engineering Dhaka University of Engineering & Technology Gazipur Bangladesh.
Md Enamul HaqueDepartment of Biotechnology and Genetic Engineering Gopalganj Science and Technology University Gopalganj Bangladesh.
Abdullah-Al-JubayerDepartment of Biotechnology and Genetic Engineering Gopalganj Science and Technology University Gopalganj Bangladesh.
Md Faruk HasanDepartment of Microbiology University of Rajshahi Bangladesh.ORCID https://orcid.org/0000-0003-2746-5994
F M Ali HaydarDepartment of Botany University of Rajshahi Rajshahi Bangladesh.
Md KhalekuzzamanDepartment of Genetic Engineering and Biotechnology University of Rajshahi Rajshahi Bangladesh.
Md Torequl IslamDepartment of Pharmacy Gopalganj Science and Technology University Gopalganj Bangladesh.
Sohel HasanDepartment of Biochemistry and Molecular Biology Gopalganj Science and Technology University Gopalganj Bangladesh.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Tuberculosis (TB) remains a major global health problem, and treatment progress is increasingly threatened by rising multidrug-resistant tuberculosis (MDR-TB). Delamanid (DLM), a nitroimidazole drug, has shown good efficacy and safety against both drug-susceptible and drug-resistant Methods: A comprehensive literature search was performed using WHO publications and major scientific databases, including PubMed, Web of Science, Embase, Scopus, and the Cochrane Library. Studies published through 2024 and early 2025 on DLM resistance, mechanisms of action, DST, pharmacokinetics, safety, and treatment outcomes were included. Structural analyses of key proteins involved in DLM activation were carried out using crystal structures and AlphaFold models. Results: Recent research identified multiple mutations in the F420-dependent activation pathway, particularly in Conclusion: DLM is an important and effective component of MDR-/XDR-TB treatment. A clearer understanding of its resistance mechanisms, pharmacological properties, and clinical outcomes can support better regimen design and help prevent the development of further resistance.

Indexed as

delamaniddrug‐resistancemolecular mechanismtreatment efficacytuberculosis

Identifiers

PMID42094621
PMCPMC13139648

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.