ArticleTheranostics2026
EGFR-19del nuclear translocation increases HDAC7 expression inhibiting the Hippo pathway and exacerbating TKI resistance in lung adenocarcinoma.
Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Rationale: Epidermal growth factor receptor (EGFR) "membrane-cytoplasmic-nuclear translocation" occurs in EGFR-19del lung adenocarcinoma (LUAD) following resistance to tyrosine kinase inhibitors (TKIs). This study aimed to elucidate the mechanism of TKI resistance conferred by nuclear EGFR-19del. Methods: RNA sequencing and immunohistochemistry were performed to assess histone deacetylase 7 (HDAC7) expression in LUAD with TKI resistance. Functional assays were performed both Results: EGFR-19del nuclear translocation correlated with elevated HDAC7 expression in TKI-resistant cells. HDAC7 overexpression promoted malignancy and reduced TKI sensitivity, whereas HDAC7 knockdown or TSA treatment suppressed tumour growth and enhanced TKI sensitivity Conclusions: We elucidated the underlying mechanism by which nuclear EGFR-19del inhibits the Hippo pathway; these results indicate that TKIs and HDAC inhibitors may serve as a potential therapeutic strategy to reduce drug resistance in LUAD with EGFR-19del.
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