Evidence map›Paper›PMID 42094608›Full record

ArticleTheranostics2026

Bioinspired Nanoplatform Potentiates Sonodynamic Immunotherapy by Remodeling the Antioxidant Tumor Microenvironment and Activating STING pathway.

Yuanyuan Zhang, Wenxiang Zhu, Kaimin Li, Yun Xie, Zhichao Deng, Yuanyuan Zhu, Bowen Gao, Chenxi Xu, Junlong Fu, Mingzhen Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuanyuan ZhangThe Clinical Laboratory, Northwest Women's and Children's Hospital, Xi'an, Shaanxi, 710061, China.
Wenxiang ZhuNanozyme Laboratory in Zhongyuan, Henan Academy of Innovations in Medical Science, Zhengzhou, Henan, 451163, China.
Kaimin LiSchool of Biological and Medical Engineering, Beijing University of Aeronautics and Astronautics, Beijing, 100191, China.
Yun XieThe Clinical Laboratory, Northwest Women's and Children's Hospital, Xi'an, Shaanxi, 710061, China.
Zhichao DengSchool of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Yuanyuan ZhuSchool of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Bowen GaoSchool of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Chenxi XuSchool of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Junlong FuSchool of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Mingzhen ZhangSchool of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Xiaoliang ZhengSchool of Laboratory Medicine and Bioengineering, Hangzhou Medical College, Hangzhou, Zhejiang, 310053, China.
Haifeng ZhangDepartment of Pathology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sonodynamic therapy (SDT) has emerged as a promising modality for treating deep-seated tumors. It has been demonstrated that SDT effectively induces immunogenic cell death (ICD), thereby initiating a systemic anti-tumor immune response - a process known as sonodynamic immunotherapy. However, its efficacy is severely limited by the hypoxic tumor microenvironment (TME) and elevated glutathione (GSH) levels, which together scavenge reactive oxygen species (ROS) and create a potent antioxidant barrier. Methods: Ultra-small Mn Results: Mn Conclusions: Mn

Indexed as

AntioxidantsColonic NeoplasmsImmunotherapyMembrane ProteinsNanoparticlesTumor MicroenvironmentUltrasonic TherapyAnimalsApoptosisCell Line, TumorFemaleGlutathioneHumansManganese CompoundsMiceMice, Inbred BALB CAntioxidantsGlutathioneManganese Compoundsmanganese oxideMembrane ProteinsOxidesReactive Oxygen SpeciesAg2S quantum dotscolon cancerImmunotherapyMn3O4 nanoparticlesSonodynamic therapy

Identifiers

PMID42094608
PMCPMC13142239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.