Evidence map›Paper›PMID 42094604›Full record

ArticleTheranostics2026

Enzyme-responsive hydrogel coating for

Xuyue Liang, Qi Tong, Zhongwu Bei, Tianying Luo, Lin Ye, Meng Pan, Yun Yang, Bingyang Chu, Yongjun Qian, Zhiyong Qian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xuyue LiangDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Qi TongDepartment of Cardiovascular Surgery, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Zhongwu BeiDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Tianying LuoDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Lin YeDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Meng PanDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Yun YangResearch Laboratory of Plastic and Burns Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
Bingyang ChuDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Yongjun QianDepartment of Cardiovascular Surgery, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Zhiyong QianDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Bioprosthetic heart valves (BHVs) replacement serves as a critical treatment for severe valvular heart disease. However, it often faces irreversible damage caused by thrombosis, inflammation, and calcification, severely limiting its therapeutic value for younger patients. Methods: Herein, we construct a biomimetic hydrogel coating loaded with cerium dioxide nanoparticles and vascular endothelial growth factor on the surface of BHVs material. This design aims to suppress material-induced thrombosis and inflammation, modulate the local microenvironment, achieve Results: The findings demonstrate that the hydrogel coating improved the antithrombotic and anti-inflammatory properties of the BHVs material. Furthermore, i Conclusion: The hydrogel coating system developed in this study promoted

Indexed as

BioprosthesisCoated Materials, BiocompatibleHeart Valve ProsthesisHeart ValvesHydrogelsAnimalsCeriumHumansMaleNanoparticlesRatsRats, Sprague-DawleyVascular Endothelial Growth Factor ACeriumCoated Materials, BiocompatibleHydrogelsVascular Endothelial Growth Factor Aantithromboticbioprosthetic heart valveshydrogel coatingimmunomodulationre-endothelialization

Identifiers

PMID42094604
PMCPMC13142126

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.