Evidence map›Paper›PMID 42094602›Full record

ArticleTheranostics2026

Pretargeted

Sara S Rinne, Niloufar Salehi, Brett A Vaughn, Daniela Burnes Vargas, Hongfen Guo, Sang Gyu Lee, Claire Vanpouille-Box, Ileana C Miranda, Brian W Miller, Edward K Fung and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sara S RinneDepartment of Radiology, Weill Cornell Medicine, New York, NY, 10065, USA.
Niloufar SalehiDepartment of Radiology, Weill Cornell Medicine, New York, NY, 10065, USA.
Brett A VaughnDepartment of Radiology, Weill Cornell Medicine, New York, NY, 10065, USA.
Daniela Burnes VargasDepartment of Radiology, Weill Cornell Medicine, New York, NY, 10065, USA.
Hongfen GuoDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Sang Gyu LeeDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Claire Vanpouille-BoxDepartment of Radiation Oncology, Weill Cornell Medicine, New York, NY, 10065, USA.
Ileana C MirandaLaboratory of Comparative Pathology, Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center, and The Rockefeller University, New York, NY, 10065, USA.
Brian W MillerDepartment of Radiation Oncology and Medical Imaging, University of Arizona, Tucson, AZ, 85724, USA.
Edward K FungDepartment of Radiology, Weill Cornell Medicine, New York, NY, 10065, USA.
Steven M LarsonDepartment of Radiology, Weill Cornell Medicine, New York, NY, 10065, USA.
Darren R VeachDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Nai-Kong V CheungDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Sarah M ChealDepartment of Radiology, Weill Cornell Medicine, New York, NY, 10065, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Rationale: Combining targeted alpha and beta therapy may address challenges such as toxicity, treatment resistance, and tumor heterogeneity. We evaluated the feasibility and therapeutic effectiveness of a DOTA-PRIT approach using a Methods: A three-step pretargeting regimen was employed: an anti-GPA33/anti-DOTA bispecific antibody (BsAb), a dendrimeric clearing agent, and radioligands labeled with Results: Biodistribution and autoradiography confirmed that the Conclusions: Our findings confirm the feasibility of a combined

Indexed as

ActiniumColorectal NeoplasmsLutetiumRadioisotopesAnimalsAutoradiographyCell Line, TumorDisease Models, AnimalFemaleHistocytochemistryHumansMiceTissue DistributionTreatment OutcomeActiniumActinium-225LutetiumLutetium-177Radioisotopes177Lu225Accombination therapyDOTA-PRITpretargeting

Identifiers

PMID42094602
PMCPMC13141694

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.