Evidence map›Paper›PMID 42094576›Full record

ArticlebioRxiv : the preprint server for biology2026

Opioid withdrawal engages a habenular subpopulation responsive to aversive states.

Leah G Blankenship, Vincent Moore, Blake Holcomb, Isabella Salinas, Emily L Sylwestrak

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Leah G BlankenshipDepartment of Biology, University of Oregon, Franklin Blvd, Eugene, OR 97403.ORCID 0000-0002-0185-808X
Vincent MooreInstitute of Neuroscience, University of Oregon, Franklin Blvd, Eugene, OR 97403.
Blake HolcombInstitute of Neuroscience, University of Oregon, Franklin Blvd, Eugene, OR 97403.ORCID 0000-0003-3315-595X
Isabella SalinasDepartment of Biology, University of Oregon, Franklin Blvd, Eugene, OR 97403.
Emily L SylwestrakDepartment of Biology, University of Oregon, Franklin Blvd, Eugene, OR 97403.ORCID 0000-0002-1172-6523

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Opioid withdrawal produces a protracted aversive state that is a driving factor towards relapse for patients with opioid use disorder. The habenula is known to mediate symptoms of withdrawal across several substance use disorders, including alcohol, nicotine, and opioid use disorder. However, it is unclear which habenular populations contribute to withdrawal symptoms. Here, we identify a cell type marker for habenular neurons active during opioid withdrawal. Using immediate early gene analysis, we find that glutamic acid decarboxylase 2-expressing (GAD2

Identifiers

PMID42094576
PMCPMC13142358

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.