Evidence map›Paper›PMID 42094574›Full record

ArticlebioRxiv : the preprint server for biology2026

Oncogene-Mechanics Axis: KRAS G12C Confers Agility Enabling Malignant Mechano-responses to Peristalsis in Colorectal Cancer.

Astha Lamichhane, Vsevolod Cheburkanov, Mykyta Kizilov, Abhinav Shenoy, Audrey G Head, Vladislav Yakovlev, Shreya A Raghavan

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Astha LamichhaneDepartment of Biomedical Engineering, Texas A&M University, College Station, TX.ORCID 0000-0003-1968-7298
Vsevolod CheburkanovDepartment of Biomedical Engineering, Texas A&M University, College Station, TX.ORCID 0000-0002-0371-9091
Mykyta KizilovDepartment of Biomedical Engineering, Texas A&M University, College Station, TX.ORCID 0000-0003-2348-4194
Abhinav ShenoyDepartment of Biomedical Engineering, Texas A&M University, College Station, TX.
Audrey G HeadDepartment of Biomedical Engineering, Texas A&M University, College Station, TX.
Vladislav YakovlevDepartment of Biomedical Engineering, Texas A&M University, College Station, TX.ORCID 0000-0002-4557-1013
Shreya A RaghavanDepartment of Biomedical Engineering, Texas A&M University, College Station, TX.ORCID 0000-0002-4631-7762

Funding

3D Engineered Model of Microscopic Colorectal Cancer Liver Metastasis for Adjuvant Chemotherapy ScreensR37CA269224 · NCI · TEXAS ENGINEERING EXPERIMENT STATION · PI Shreya A. Raghavan · 2023 to 2026
$928k
NCI NIH HHS R37 CA269224
6 · The paper itself

Abstract

Oncogene activity and mechanical forces individually and collectively drive colorectal cancer, yet the integration of these signals is unknown. We used a patented peristalsis bioreactor to determine how oncogenic KRAS G12C mutations alter the cellular response to colonic peristalsis. Although both healthy intestinal cells and KRAS G12C cancer cells sensed peristalsis via ERK phosphorylation, their mechano-responses diverged significantly. Peristalsis triggered a 9-fold enrichment of LGR5

Indexed as

Brillouin microscopyCancer mechanobiologyoncogeneperistalsisviscosity

Identifiers

PMID42094574
PMCPMC13142439

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.