Evidence map›Paper›PMID 42094571›Full record

ArticlebioRxiv : the preprint server for biology2026

Parkinson's disease-associated LRRK2 risk variant, G2385R, enhances Rab substrate phosphorylation and impairs neuronal integrity.

An Phu Tran Nguyen, Roger Moser, Nicole Bryant, Lindsey A Cunningham, Evan J Worden, Darren J Moore

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

An Phu Tran NguyenDepartments of Neurodegenerative Science, Van Andel Institute, Grand Rapids, Michigan 49503, USA.
Roger MoserLaboratory of Molecular Neurodegenerative Research, Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland.
Nicole BryantCenter for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC 27710, USA.
Lindsey A CunninghamDepartments of Neurodegenerative Science, Van Andel Institute, Grand Rapids, Michigan 49503, USA.
Evan J WordenDepartments of Structural Biology, Van Andel Institute, Grand Rapids, Michigan 49503, USA.
Darren J MooreDepartments of Neurodegenerative Science, Van Andel Institute, Grand Rapids, Michigan 49503, USA.ORCID 0000-0003-2359-5679

Funding

LRRK2 Enzymatic Mechanisms of Neurodegeneration in Parkinson's DiseaseR01NS120489 · NINDS · VAN ANDEL RESEARCH INSTITUTE · PI MOORE, DARREN JOHN · 2021 to 2025
$2.3M
NINDS NIH HHS R01 NS120489
6 · The paper itself

Abstract

Mutations in the

Identifiers

PMID42094571
PMCPMC13142482

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.