Evidence map›Paper›PMID 42094546›Full record

ArticlebioRxiv : the preprint server for biology2026

CRISPR inhibition of activity-dependent Arc expression in the adult mouse brain has limited effects on plasticity in visual cortex and nucleus accumbens.

Aaron T Halvorsen, Arthy Narayanan, Grace M Link, Thomas J Wagner, Ashleigh K Waterman, Mara H Cowen, Katherine R Tonn Eisinger, Lindsey L Glickfeld, Anne E West

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aaron T HalvorsenDepartment of Neurobiology, Duke University, Durham, NC 27710.
Arthy NarayananDepartment of Neurobiology, Duke University, Durham, NC 27710.
Grace M LinkDepartment of Neurobiology, Duke University, Durham, NC 27710.
Thomas J WagnerDepartment of Neurobiology, Duke University, Durham, NC 27710.
Ashleigh K WatermanDepartment of Neurobiology, Duke University, Durham, NC 27710.
Mara H CowenDepartment of Neurobiology, Duke University, Durham, NC 27710.
Katherine R Tonn EisingerDepartment of Neurobiology, Duke University, Durham, NC 27710.
Lindsey L GlickfeldDepartment of Neurobiology, Duke University, Durham, NC 27710.
Anne E WestDepartment of Neurobiology, Duke University, Durham, NC 27710.ORCID 0000-0003-0846-139X

Funding

Using epigenome editing of transcriptional enhancers to regulate adult visual cortical plasticityR21EY032335 · NEI · DUKE UNIVERSITY · PI GLICKFELD, LINDSEY L, WEST, ANNE ELIZABETH · 2022 to 2023
$443k
NEI NIH HHS R21 EY032335
6 · The paper itself

Abstract

Neuronal activity drives long-lasting change in circuit function by inducing the expression of gene products that modulate the function of synapses.

Identifiers

PMID42094546
PMCPMC13142304

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.