Evidence map›Paper›PMID 42094514›Full record

ArticlebioRxiv : the preprint server for biology2026

Mutation of a single cysteine in CaMKIIδ protects the heart from ischemia-reperfusion Injury.

Nathália Rocco-Machado, Junhui Sun, Audrey Noguchi, Danielle A Springer, Chengyu Liu, Elizabeth Murphy, Rodney L Levine

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nathália Rocco-MachadoLaboratory of Biochemistry, National Heart, Lung and Blood Institute, Bethesda, Maryland, United States of America.
Junhui SunCardiac Physiology Lab, Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Audrey NoguchiMurine Phenotyping Core, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America.
Danielle A SpringerMurine Phenotyping Core, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America.
Chengyu LiuTransgenic Core, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America.
Elizabeth MurphyCardiac Physiology Lab, Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Rodney L LevineLaboratory of Biochemistry, National Heart, Lung and Blood Institute, Bethesda, Maryland, United States of America.

Funding

Oxidative Modification Of ProteinsZIAHL000225 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVINE, RODNEY L. · 2009 to 2025
$35.2M
Intramural NIH HHS ZIA HL000225
6 · The paper itself

Abstract

CaMKIIδ is the dominant isozyme of Ca

Indexed as

Ca2+/calmodulin-dependent protein kinase II deltaCysteineIschemia-reperfusion injuryOxidative stressRedox regulation

Identifiers

PMID42094514
PMCPMC13142510

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.