ArticlebioRxiv : the preprint server for biology2026
A bifidobacterial enzyme orchestrates ecology and function of infant gut bacterial community.
Yangwei Shan, Nicholas Pucci, Coen Berns, Rick Hoogendijk, Myrthe Beijnvoort, Shijia Li, Alejandro Sánchez-Cano, Gertjan Kramer, Wei Du, Daniel R Mende and 3 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors.
Yangwei ShanDepartment of Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, The Netherlands.ORCID 0000-0001-6902-552X Nicholas PucciDepartment of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Coen BernsDepartment of Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, The Netherlands.ORCID 0000-0002-9675-9083 Rick HoogendijkDepartment of Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, The Netherlands.
Myrthe BeijnvoortDepartment of Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, The Netherlands.
Shijia LiDepartment of Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, The Netherlands.
Alejandro Sánchez-CanoBiosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam The Netherlands.
Gertjan KramerDepartment of Mass Spectrometry of Biomolecules, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, The Netherlands.ORCID 0000-0002-8541-0337 Wei DuMolecular Microbial Physiology Group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands.
Daniel R MendeDepartment of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Amsterdam, The Netherlands.ORCID 0000-0001-6831-4557 Aalt Dirk Jan van DijkBiosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam The Netherlands.ORCID 0000-0002-8872-5123 Meike WortelDepartment of Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, The Netherlands.ORCID 0000-0002-3191-2710 Jianbo ZhangDepartment of Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, The Netherlands.ORCID 0000-0003-3526-4586 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Human milk oligosaccharides (HMOs) are abundant and structurally diverse glycans that shape the development of infant gut microbiota. Yet, how individual HMOs and bacterial genes drive the community assembly remain elusive. Here, we reconstructed an eight-member infant Bacterial Community (iBaCo) from representing dominant taxa in human infant feces. When individual HMOs were the sole carbohydrate source, they showed deterministic effects on the iBaCo composition and metabolic output. Notably, the tetramer HMO lacto-N-tetraose (LNT), in spite of its identical monomer composition as lacto-N-neotetraose (LNnT), showed a strong effect on maintaining
Indexed as
BifidobacteriumHuman milk oligosaccharidesiBaCoInfant gut microbiotaβ-galactosidase
Identifiers
PMID42094492
PMCPMC13142491
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