Evidence map›Paper›PMID 42094485›Full record

ArticlebioRxiv : the preprint server for biology2026

Connectome simulations identify a central pattern generator circuit for fly walking.

Sarah M Pugliese, Grant M Chou, Elliott T T Abe, Denis Turcu, Jackson K Lancaster, John C Tuthill, Bingni W Brunton

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah M PuglieseGraduate Program in Neuroscience, University of Washington, Seattle, WA, USA.ORCID 0009-0004-1745-3564
Grant M ChouDept of Neurobiology & Biophysics, University of Washington, Seattle, WA, USA.ORCID 0009-0001-3003-2631
Elliott T T AbeDept of Biology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-5305-2467
Denis TurcuAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-2955-2568
Jackson K LancasterDept of Biology, University of Washington, Seattle, WA, USA.
John C TuthillDept of Neurobiology & Biophysics, University of Washington, Seattle, WA, USA.ORCID 0000-0002-5689-5806
Bingni W BruntonDept of Biology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-4831-3466

Funding

Understanding Sensorimotor Control Through Realistic Neuro-Biomechanical SimulationU01NS136507 · NINDS · HARVARD UNIVERSITY · PI Bingni Wen Brunton, Bence P Olveczky · 2024 to 2026
$7.1M
Neural coding of leg proprioceptionR01NS102333 · NINDS · UNIVERSITY OF WASHINGTON · PI John Tuthill · 2017 to 2026
$3.6M
The Functional Role and Neural Basis of Rapid Turns in Olfactory Search BehaviorR01NS136988 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Bingni Wen Brunton, Michael H Dickinson · 2024 to 2026
$3.3M
Proprioceptive Detection of Joint Limits and Its Role in Limb Sensorimotor ControlR01NS145438 · NINDS · UNIVERSITY OF WASHINGTON · PI Bingni Wen Brunton, John Tuthill · 2025 to 2026
$1.2M
Dissecting circuit and cellular mechanisms for limb motor controlR01NS128785 · NINDS · UNIVERSITY OF WASHINGTON · PI John Tuthill · 2025 to 2026
$643k
NINDS NIH HHS R01 NS102333NINDS NIH HHS R01 NS128785NINDS NIH HHS R01 NS136988NINDS NIH HHS R01 NS145438NINDS NIH HHS U01 NS136507
6 · The paper itself

Abstract

Animal locomotion relies on rhythmic body movements driven by central pattern generators (CPGs): neural circuits that produce oscillating output without oscillating input. However, the circuit structure of a CPG for walking is not known in any animal. To identify the cells and synapses that underlie rhythmic leg movement in walking flies, we developed dynamic simulations of the

Identifiers

PMID42094485
PMCPMC13142387

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.