Evidence map›Paper›PMID 42094481›Full record

ArticlebioRxiv : the preprint server for biology2026

Cell-state mapping reveals a reversible neuroblast accumulation in the aging mouse hippocampus.

Natalí B Rasetto, Magalí Herrero, Ariel A Berardino, Daniela J Di Bella, Damiana Giacomini, Mariela F Trinchero, Paola Arlotta, Ariel Chernomoretz, Alejandro F Schinder

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Natalí B Rasetto *Instituto de Investigaciones Bioquímicas de Buenos Aires (IIBBA) - CONICET, Argentina.
Magalí Herrero *Instituto de Investigaciones Bioquímicas de Buenos Aires (IIBBA) - CONICET, Argentina.
Ariel A BerardinoInstituto de Investigaciones Bioquímicas de Buenos Aires (IIBBA) - CONICET, Argentina.
Daniela J Di BellaDept. of Stem Cells and Regenerative Biology, Harvard University & Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Damiana GiacominiInstituto de Investigaciones Bioquímicas de Buenos Aires (IIBBA) - CONICET, Argentina.
Mariela F TrincheroInstituto de Investigaciones Bioquímicas de Buenos Aires (IIBBA) - CONICET, Argentina.
Paola ArlottaDept. of Stem Cells and Regenerative Biology, Harvard University & Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ariel ChernomoretzInstituto de Investigaciones Bioquímicas de Buenos Aires (IIBBA) - CONICET, Argentina.
Alejandro F SchinderInstituto de Investigaciones Bioquímicas de Buenos Aires (IIBBA) - CONICET, Argentina.ORCID 0000-0003-4863-8348

Funding

Molecular principles of neuronal maturation and integration in the adult and aging brainR01NS103758 · NINDS · HARVARD UNIVERSITY · PI ARLOTTA, PAOLA, SCHINDER, ALEJANDRO FABIAN · 2018 to 2022
$2.7M
Neuron-Oligodendrocyte Communication Underlying Myelin Distribution in the NeocortexR01NS128117 · NINDS · HARVARD UNIVERSITY · PI Paola Arlotta · 2022 to 2026
$2.1M
NINDS NIH HHS R01 NS103758NINDS NIH HHS R01 NS128117
6 · The paper itself

Abstract

Hippocampal neurogenesis supports learning and memory by generating new granule cells throughout life. However, both the rate and speed of this process decline with age. To elucidate the molecular determinants underlying the effects of aging on neuronal differentiation, we combined lineage tracing of adult-born granule cells (aGCs) with single-nucleus RNA sequencing. This approach produced a temporally resolved transcriptional atlas of aGC development. Aging led to a marked accumulation of postmitotic neuroblasts (NBs), revealing a stage-specific bottleneck in the neurogenic trajectory. Voluntary running reduced NB accumulation by restoring the progression through this developmental impasse, allowing neuronal maturation to be resumed. Notably, this effect involved a significant reduction of apoptosis at the NB stage. Together, these findings identify a reversible apoptotic checkpoint that contributes to age-related neurogenic decline and highlight postmitotic NBs as a key regulatory cell state capable of integrating pro-maturational signals to control the neurogenic output.

Indexed as

activity-dependent plasticityadult neurogenesisExerciseneuronal developmentsnRNA-seq

Identifiers

PMID42094481
PMCPMC13142477

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.