ArticlebioRxiv : the preprint server for biology2026
Inherent Specificity and Variation Sensitivity as Quantitative Metrics for RBP Binding.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
RNA-binding proteins (RBPs) regulate every aspect of post-transcriptional gene expression, yet our ability to compare how selectively different RBPs recognize their targets remains limited. Binding affinity, expressed as a dissociation constant, provides a universal quantity for comparing binding strength, but no equivalent metric exists for binding specificity. Here we introduce two quantitative metrics to fill this gap: inherent specificity, which measures how selectively an RBP distinguishes its strongest binding motif from all other sequences, and variation sensitivity, which measures tolerance to single nucleotide changes within that motif. Analyzing high-throughput sequencing data across 100 RBPs
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