Evidence map›Paper›PMID 42094443›Full record

ArticlebioRxiv : the preprint server for biology2026

Dual inhibition of GTP-bound (ON) and GDP-bound (OFF) KRAS

Katherine Parker, Samar Ghorbanpoor, Wafa Malik, Lauren Highfield, Jamie Wang, Emily Hensley, Grace Kelley, Sarah Clark, Michela Ranieri, Soumyadip Sahu and 16 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Katherine ParkerKrantz Family Center for Cancer Research, Mass General Brigham Cancer Institute, Boston MA USA.
Samar GhorbanpoorKrantz Family Center for Cancer Research, Mass General Brigham Cancer Institute, Boston MA USA.
Wafa MalikKrantz Family Center for Cancer Research, Mass General Brigham Cancer Institute, Boston MA USA.
Lauren HighfieldKrantz Family Center for Cancer Research, Mass General Brigham Cancer Institute, Boston MA USA.
Jamie WangKrantz Family Center for Cancer Research, Mass General Brigham Cancer Institute, Boston MA USA.
Emily HensleyKrantz Family Center for Cancer Research, Mass General Brigham Cancer Institute, Boston MA USA.
Grace KelleyKrantz Family Center for Cancer Research, Mass General Brigham Cancer Institute, Boston MA USA.
Sarah ClarkKrantz Family Center for Cancer Research, Mass General Brigham Cancer Institute, Boston MA USA.
Michela RanieriLaura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York NY USA.
Soumyadip SahuLaura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York NY USA.
Cathy ZhangBBOT, South San Francisco CA USA.
Magdalena PloszajLaura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York NY USA.
Daniel AndrussierLaura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York NY USA.
Hsin-Yi HuangLaura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York NY USA.
Ting ChenLaura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York NY USA.
Bin WangBBOT, South San Francisco CA USA.
Rui XuBBOT, South San Francisco CA USA.
Saman SetoodehBBOT, South San Francisco CA USA.
Ken LinBBOT, South San Francisco CA USA.
Anna E MaciagNCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland.
Frank McCormickHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA USA.
Pedro J BeltranBBOT, South San Francisco CA USA.
Kwok-Kin WongLaura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York NY USA.
James P SticeBBOT, South San Francisco CA USA.
Kerstin W SinkeviciusBBOT, South San Francisco CA USA.
Aaron N HataKrantz Family Center for Cancer Research, Mass General Brigham Cancer Institute, Boston MA USA.

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
NIH HHS 75N91019D00024
6 · The paper itself

Abstract

Current approved KRAS

Identifiers

PMID42094443
PMCPMC13142521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.