ArticlebioRxiv : the preprint server for biology2026
Fibroblast Growth Factor Receptor Signaling in Maturing Osteoblasts Controls Cell-Matrix Interactions Critical for Osteocyte Survival.
Debabrata Patra, Craig Smith, Chenming Wei, Courtney M Mazur, Ilemona Ameadaji, Tiandao Li, Marc N Wein, Mathew J Silva, David M Ornitz
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Debabrata PatraDepartment of Developmental Biology, Washington University School of Medicine and McKelvey School of Engineering, Washington University, St. Louis, MO 63110 USA.ORCID 0000-0001-8606-1573 Craig SmithDepartment of Developmental Biology, Washington University School of Medicine and McKelvey School of Engineering, Washington University, St. Louis, MO 63110 USA.
Chenming WeiDepartment of Orthopaedic Surgery, Washington University School of Medicine and McKelvey School of Engineering, Washington University, St. Louis, MO 63110 USA.
Courtney M MazurEndocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 USA.ORCID 0000-0003-1143-5483 Ilemona AmeadajiDepartment of Developmental Biology, Washington University School of Medicine and McKelvey School of Engineering, Washington University, St. Louis, MO 63110 USA.
Tiandao LiDepartment of Developmental Biology, Washington University School of Medicine and McKelvey School of Engineering, Washington University, St. Louis, MO 63110 USA.
Marc N WeinEndocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 USA.ORCID 0000-0002-6015-8147 Mathew J SilvaDepartment of Orthopaedic Surgery, Washington University School of Medicine and McKelvey School of Engineering, Washington University, St. Louis, MO 63110 USA.
David M OrnitzDepartment of Developmental Biology, Washington University School of Medicine and McKelvey School of Engineering, Washington University, St. Louis, MO 63110 USA.
Funding
TRAINING PROGRAM IN ENDOCRINOLOGY AND DIABETEST32DK007028 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Karen K Miller · 1986 to 2026
$18.5MResponse of the Osteoporotic Skeleton to Mechanical LoadingR01AR047867 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2001 to 2026
$8.4MResource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI DEBORAH J VEIS · 2019 to 2026
$6.8MThe role of salt inducible kinases in parathyroid hormone action in boneR01DK116716 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Marc Nathan Wein · 2018 to 2026
$3.8MRegulation of Osteocyte Survival by Fibroblast Growth Factor Signaling PathwaysR01AR079246 · NIAMS · WASHINGTON UNIVERSITY · PI David M Ornitz · 2022 to 2026
$2.5MThe Dynamic Range of Site-1 Protease Functions in Skeletal DevelopmentR01AR066590 · NIAMS · WASHINGTON UNIVERSITY · PI PATRA, DEBABRATA, SANDELL, LINDA J · 2015 to 2019
$1.7MTrafficking and translation of mRNA in osteocyte dendritesF32AR081660 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI MAZUR, COURTNEY MARISA · 2022 to 2024
$91kNIAMS NIH HHS F32 AR081660NIAMS NIH HHS P30 AR074992NIAMS NIH HHS R01 AR047867NIAMS NIH HHS R01 AR066590NIAMS NIH HHS R01 AR079246NIDDK NIH HHS R01 DK116716NIDDK NIH HHS T32 DK007028
6 · The paper itselfAbstract
The terminal differentiation of osteoblasts into osteocytes, the most abundant cell type in cortical bone, is critical for skeletal homeostasis. Osteocyte loss is a hallmark of bone aging and fragility, yet the mechanisms regulating osteocyte formation and survival are poorly understood. We show that inactivation of fibroblast growth factor receptor 1 (
Indexed as
ApoptosisBone MatrixCollagenOsteoblastOsteocalcinOsteocyteOsteoidPodoplanin
Identifiers
PMID42094430
PMCPMC13142311
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