Evidence map›Paper›PMID 42094423›Full record

ArticlebioRxiv : the preprint server for biology2026

Prenatal THC exposure disrupts mitochondrial respiratory gene programs and medium spiny neuron maturation trajectories in the nucleus accumbens.

Zhong Chen, Wanqiu Chen, Yun Seok Lee, Wendell Jones, Laura Goetzl, Jennifer Dawn Thomas, Yan Dong, Charles Wang

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhong ChenCenter for Genomics, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA.
Wanqiu ChenCenter for Genomics, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA.
Yun Seok LeeCenter for Genomics, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA.
Wendell JonesIQVIA Laboratories Genomics, Durham, NC, USA.
Laura GoetzlDepartment of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School, University of Texas Health at Houston, Houston, TX 77030, USA.
Jennifer Dawn ThomasCenter for Behavioral Teratology, San Diego State University, San Diego, CA 92120, USA.
Yan DongDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Charles WangCenter for Genomics, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA.ORCID 0000-0001-8861-2121

Funding

Genomic and Epigenomic Mechanisms of Maternal E-Cigarette induced Abnormal Brain DevelopmentU01DA058278 · NIDA · LOMA LINDA UNIVERSITY · PI Charles Wang, DALIAO XIAO · 2023 to 2026
$4.4M
High Throughput DNA SequencerS10OD019960 · OD · LOMA LINDA UNIVERSITY · PI WANG, CHARLES · 2015 to 2015
$272k
NIDA NIH HHS U01 DA058278NIH HHS S10 OD019960
6 · The paper itself

Abstract

Prenatal cannabis exposure (PCE) is increasingly prevalent and has been associated with adverse neurodevelopmental outcomes, yet its molecular impact on brain reward circuitry remains poorly defined. Here, we investigated transcriptional and epigenomic alterations in the nucleus accumbens (NAc) following prenatal Δ

Identifiers

PMID42094423
PMCPMC13142399

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.