Evidence map›Paper›PMID 42094413›Full record

ArticlebioRxiv : the preprint server for biology2026

Improved sensors for fructose-1,6-bisphosphate enable in vivo imaging of glycolysis.

Juliann Tyler, Anjali Amrapali Vishwanath, Triveni Menon, Tanishqua Duarah, Raghabendra Adhikari, John N Koberstein, Daniel Feliciano, Isabel Espinosa-Medina, Daniel Colón-Ramos, Alison G Tebo

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Juliann TylerHoward Hughes Medical Institute - Janelia Research Campus, Ashburn, VA, USA.
Anjali Amrapali VishwanathDepartment of Neuroscience and Cell Biology, Yale University School of Medicine, New Haven, CT 06536.
Triveni MenonHoward Hughes Medical Institute - Janelia Research Campus, Ashburn, VA, USA.
Tanishqua DuarahHoward Hughes Medical Institute - Janelia Research Campus, Ashburn, VA, USA.
Raghabendra AdhikariHoward Hughes Medical Institute - Janelia Research Campus, Ashburn, VA, USA.
John N KobersteinHoward Hughes Medical Institute - Janelia Research Campus, Ashburn, VA, USA.
Daniel FelicianoHoward Hughes Medical Institute - Janelia Research Campus, Ashburn, VA, USA.
Isabel Espinosa-MedinaHoward Hughes Medical Institute - Janelia Research Campus, Ashburn, VA, USA.
Daniel Colón-RamosHoward Hughes Medical Institute - Janelia Research Campus, Ashburn, VA, USA.ORCID 0000-0003-0223-7717
Alison G TeboHoward Hughes Medical Institute - Janelia Research Campus, Ashburn, VA, USA.ORCID 0000-0003-0788-5617

Funding

Examination of the cell biology of the synapse and behaviorR35NS132156 · NINDS · YALE UNIVERSITY · PI DANIEL A COLON-RAMOS · 2023 to 2026
$4.6M
NINDS NIH HHS R35 NS132156
6 · The paper itself

Abstract

Fructose-1,6-bisphosphate (FBP) is the product of the first committed step of glycolysis, and its concentration is tightly correlated with glycolytic flux. Glycolytic activity varies across tissues and cell types: some tissues, such as the brain, dynamically regulate glycolysis in response to demand, while others, such as the liver have characterized spatial heterogeneity. Here, we report HYlight2, an improved sensor for FBP developed through random whole-gene mutagenesis in

Identifiers

PMID42094413
PMCPMC13142542

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.