Evidence map›Paper›PMID 42094394›Full record

ArticlebioRxiv : the preprint server for biology2026

Murine osteosarcoma recapitulates the driver landscape and genomic complexity of osteosarcoma evolution in humans.

Geoffrey A Smith, Ianthe A E M van Belzen, Mathieu Epinette, Emilia Herdes, Kim L Mercer, Charlotte G Butterworth, Alistair G Rust, Adrienne M Flanagan, Matthew G Jones, Isidro Cortes-Ciriano and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Geoffrey A SmithDana-Farber/Boston Children's Cancer and Blood Disorders Center; Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1638-4219
Ianthe A E M van BelzenEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK.ORCID 0000-0003-2377-3586
Mathieu EpinetteKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA USA.ORCID 0000-0002-8171-9476
Emilia HerdesKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA USA.ORCID 0009-0009-8848-7362
Kim L MercerKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA USA.ORCID 0000-0002-8525-483X
Charlotte G ButterworthEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK.ORCID 0000-0002-9416-6057
Alistair G RustEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK.ORCID 0000-0001-7287-192X
Adrienne M FlanaganEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK.ORCID 0000-0002-2832-1303
Matthew G JonesKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA USA.
Isidro Cortes-CirianoEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK.ORCID 0000-0002-2036-494X
Tyler JacksKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA USA.ORCID 0000-0001-5785-8911

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Jacqueline A. Lees · 1985 to 2026
$93.9M
NCI NIH HHS P30 CA014051
6 · The paper itself

Abstract

Osteosarcoma (OS) genomes are characterized by complex genomic rearrangements (CGRs) that drive genomic instability and clonal diversification early in tumor evolution. As a result, OS tumors display high inter-patient variability, which has hindered molecular stratification and targeted therapeutic development. To study genomic complexity in OS and credential a genetically engineered mouse model of the disease (

Identifiers

PMID42094394
PMCPMC13142425

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.