Evidence map›Paper›PMID 42094367›Full record

ArticlebioRxiv : the preprint server for biology2026

Coenzyme A is a redox sensing cofactor for malic enzyme 2 regulating oxidative stress and mitochondrial metabolism.

Wenzhe Chen, Ornella D Nelson, Xiaorong Li, Manfeng Zhang, Xuan Lu, Tao Yu, Cong-Hui Yao, Shuai Zhang, Yugang Zhang, Adam Francisco and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Wenzhe ChenDepartment of Medicine and Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Ornella D NelsonDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, USA.
Xiaorong LiState Key Laboratory of Animal Biotech Breeding and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, China.
Manfeng ZhangState Key Laboratory of Animal Biotech Breeding and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, China.
Xuan LuDepartment of Medicine and Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Tao YuDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, USA.
Cong-Hui YaoBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA, 60637.
Shuai ZhangDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, USA.
Yugang ZhangDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, USA.
Adam FranciscoDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, USA.ORCID 0000-0001-8462-6569
Byunghyun AhnDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, USA.
Em LundbergDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Minsu SongDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Janane F RahbaniDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Zhongzhou ChenState Key Laboratory of Animal Biotech Breeding and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, China.
Hening LinDepartment of Medicine and Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-0255-2701

Funding

CHEMISTRY OF BIOLOGICAL SYSTEMST32GM008500 · NIGMS · CORNELL UNIVERSITY ITHACA · PI LIN, HENING · 1996 to 2020
$5.4M
Metabolite Sensing and Regulation of Protein FunctionR35GM131808 · NIGMS · CORNELL UNIVERSITY · PI LIN, HENING · 2019 to 2023
$1.9M
NIGMS NIH HHS R35 GM131808NIGMS NIH HHS T32 GM008500
6 · The paper itself

Abstract

Coenzyme A (CoA) is an essential cofactor required for numerous metabolic reactions, yet its ability to bind and regulate proteins remains poorly defined. Using a proteomic approach, we identified malic enzyme 2 (ME2) as a CoA-binding protein. ME2 uses NAD(P)

Identifiers

PMID42094367
PMCPMC13142473

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.