Evidence map›Paper›PMID 42094364›Full record

ArticlebioRxiv : the preprint server for biology2026

A unified photosensitizer platform for

Elijah B Biletch, Conor P Herlihy, Lidan Li, Mary Krebs, Conor J Kelly, Nicolas J Longhi, Olivia Weissenfels, Hanna G Goldberg, Kyle Brandt, Jonathan B Grimm and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Elijah B BiletchBiological Chemistry Department, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-3723-536X
Conor P HerlihyDepartment of Genome Sciences, University of Washington, Seattle, WA 98105, USA.ORCID 0000-0001-9818-4204
Lidan LiDepartment of Genome Sciences, University of Washington, Seattle, WA 98105, USA.ORCID 0000-0001-7551-4469
Mary KrebsDepartment of Genome Sciences, University of Washington, Seattle, WA 98105, USA.
Conor J KellyDepartment of Genome Sciences, University of Washington, Seattle, WA 98105, USA.ORCID 0000-0003-2410-7892
Nicolas J LonghiDepartment of Genome Sciences, University of Washington, Seattle, WA 98105, USA.
Olivia WeissenfelsDepartment of Genome Sciences, University of Washington, Seattle, WA 98105, USA.
Hanna G GoldbergBiological Chemistry Department, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Kyle BrandtDepartment of Genome Sciences, University of Washington, Seattle, WA 98105, USA.
Jonathan B GrimmJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
Luke D LavisJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.ORCID 0000-0002-0789-6343
Edward L HuttlinDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-1822-1173
Devin K SchweppeDepartment of Genome Sciences, University of Washington, Seattle, WA 98105, USA.ORCID 0000-0002-3241-6276
Keriann M BackusBiological Chemistry Department, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Brian J BeliveauDepartment of Genome Sciences, University of Washington, Seattle, WA 98105, USA.

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
RESEARCH TRAINING IN HEMATOLOGYT32HL007093 · NHLBI · UNIVERSITY OF WASHINGTON · PI Janis L Abkowitz · 1985 to 2026
$13.9M
Systematic Exploration of the Human Interactome IVU24HG006673 · NHGRI · HARVARD MEDICAL SCHOOL · PI GYGI, STEVEN P, HARPER, JEFFREY W · 2018 to 2025
$6.0M
Probing the dynamics of chromosome organization in single cellsR35GM137916 · NIGMS · UNIVERSITY OF WASHINGTON · PI Brian Joseph Beliveau · 2020 to 2026
$2.9M
A systems-level approach to decipher the protein interactome.DP2GM146246 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BACKUS, KERIANN MARIE · 2021 to 2024
$2.3M
Technology for evaluating drug-binding responses to small-molecule perturbationR35GM150919 · NIGMS · UNIVERSITY OF WASHINGTON · PI Devin Karl Schweppe · 2023 to 2026
$1.6M
NCI NIH HHS P30 CA015704NHGRI NIH HHS U24 HG006673NHLBI NIH HHS T32 HL007093NIGMS NIH HHS DP2 GM146246NIGMS NIH HHS R35 GM137916NIGMS NIH HHS R35 GM150919
6 · The paper itself

Abstract

Cells depend on the spatial organization of proteins, RNA, and DNA into discrete subcellular compartments. Previous methods have largely centered on measuring spatial organization based on only one of these biomolecular classes at a time. Here, we demonstrate that POCA photocatalytic proximity labeling can serve as a unified photosensitizer-based platform for profiling the proximal proteomes of protein, RNA, and DNA targets within a single experimental framework. We show that POCA can harness standard immunofluorescence or

Identifiers

PMID42094364
PMCPMC13142541

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.