Evidence map›Paper›PMID 42094346›Full record

ArticlebioRxiv : the preprint server for biology2026

Structural Activation of DNA Unwinding by MCM8/9/HROB.

Chuxuan Li, Colin To, Temitope M Adeleke, David R McKinzey, Yang Gao, Michael A Trakselis

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chuxuan LiDepartment of BioSciences, Rice University, Houston, TX 77030, USA.ORCID 0000-0001-9386-9909
Colin ToDepartment of Chemistry and Biochemistry, Baylor University, Waco, TX, 76798, USA.ORCID 0009-0003-4462-1423
Temitope M AdelekeDepartment of Chemistry and Biochemistry, Baylor University, Waco, TX, 76798, USA.ORCID 0009-0008-7041-6921
David R McKinzeyDepartment of Chemistry and Biochemistry, Baylor University, Waco, TX, 76798, USA.ORCID 0000-0003-0845-5352
Yang GaoDepartment of BioSciences, Rice University, Houston, TX 77030, USA.ORCID 0000-0002-4037-0431
Michael A TrakselisDepartment of Chemistry and Biochemistry, Baylor University, Waco, TX, 76798, USA.ORCID 0000-0001-7054-8475

Funding

Structural basis of replisome mediated DNA replication and repairR35GM142722 · NIGMS · RICE UNIVERSITY · PI GAO, YANG · 2021 to 2025
$1.9M
Molecular control of translesion synthesis fidelity beyond the lesionR15GM155805 · NIGMS · BAYLOR UNIVERSITY · PI Michael A Trakselis · 2024 to 2026
$481k
NIGMS NIH HHS R15 GM155805NIGMS NIH HHS R35 GM142722
6 · The paper itself

Abstract

The minichromosomal maintenance MCM8 and MCM9 proteins form a heterohexameric complex that acts to unwind or remodel duplex DNA in DNA recombination and repair pathways. Mutations or absence of MCM8/9 have been linked to infertility, sex-specific deficiencies, and several cancers. Recently, HROB has been identified as a critical cofactor of MCM8/9; however, the mechanism underlying activation of MCM8/9 DNA binding and unwinding remain unclear. Here, we present dynamic structures of MCM8/9 with DNA, HROB and ATP analogs using cryo-electron microscopy. DNA binding induces a pronounced rotational rearrangement between the N-terminal DNA binding and C-terminal AAA

Indexed as

allosterycancercryoEMhelicaseheterohexamerHROBinfertilityMCM8/9unwinding

Identifiers

PMID42094346
PMCPMC13142438

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.