Evidence map›Paper›PMID 42094343›Full record

ArticlebioRxiv : the preprint server for biology2026

In Vivo Massively Parallel Reporter Assay Reveals Sequence Determinants of mRNA Localization in Astrocytes.

S K Koester, K Sakers, G M Rurak, S P Plassmeyer, K McFarland White, S Alves Ferreira Dias, P Baird, D J Kornbluth, J D Dougherty

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

S K KoesterDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0003-4626-504X
K SakersDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.
G M RurakDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.
S P PlassmeyerDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.
K McFarland WhiteDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.
S Alves Ferreira DiasDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.
P BairdDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.
D J KornbluthDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.
J D DoughertyDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.

Funding

WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 2020 to 2026
$15.5M
Training Program in Cellular and Molecular BiologyT32GM139774 · NIGMS · WASHINGTON UNIVERSITY · PI HEATHER L TRUE-KROB · 2021 to 2026
$6.7M
HIGHLY PARALLEL ANALYSIS OF 5' AND 3' UTR VARIANTS IN NEURODEVELOPMENTAL DISORDERSR01MH116999 · NIMH · WASHINGTON UNIVERSITY · PI JOSEPH D DOUGHERTY · 2018 to 2026
$5.1M
Regulation of local translation in gliaR01NS102272 · NINDS · WASHINGTON UNIVERSITY · PI JOSEPH D DOUGHERTY · 2017 to 2026
$3.8M
NICHD NIH HHS P50 HD103525NIGMS NIH HHS T32 GM139774NIMH NIH HHS R01 MH116999NINDS NIH HHS R01 NS102272
6 · The paper itself

Abstract

RNA localization and local translation are essential mechanisms to fine-tune spatiotemporal gene expression in the nervous system. However, efficiently assessing the thousands of possible sequence determinants of RNA localization is a challenge, particularly for cell types that only reach morphological maturity

Identifiers

PMID42094343
PMCPMC13142395

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.