ArticleFrontiers in physiology2026
Synbiotic supplementation modulates humoral immunity and cecal microbiota in broiler chickens exposed to subclinical doses of fumonisins and deoxynivalenol.
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Synbiotics modulate the cecal microbiota in chickens by promoting the growth of beneficial bacteria, which have the potential to mitigate the negative effects of mycotoxins such as fumonisins (FUM) and deoxynivalenol (DON) and improve immune responses. The objective of the study was to evaluate the effect of synbiotic supplementation (0.05%) on the bile IgA, serum IgY, cecal microbiota composition, diversity, and short-chain fatty acid (SCFA) profile in broilers exposed to subclinical concentrations of FUM and DON. A total of 360 one-day-old broilers were distributed into 4 treatments: Control, Mycotoxin (8.5 FUM + 3.8 DON mg/kg diet), Synbiotic, and Mycotoxin + Synbiotic. Cecal contents were collected on d21 and d35, and bacterial compositions were identified by analyzing the V3-V4 region of the 16S rRNA gene using Illumina sequencing. Relative abundance of families and alpha diversity indices were analyzed using the Kruskal-Wallis H Test, and IgA, IgY, and short-chain fatty acids (SCFAs) were analyzed using two-way ANOVA. On d35, there were no interaction effects between FUM + DON and synbiotic supplementation on bile FUM-specific IgA concentrations and serum FUM and DON-specific IgY concentrations (
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