Low cytotoxicity of linoleic acid-derived epoxy-fatty acids in liver and colon cell lines.

Henrik Reuter, Nadja Kampschulte, Kathrin Plitzko, Katja Mosel, Christophe Morisseau, Nils Helge Schebb

Abstract read

In one paragraph

Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Henrik ReuterFood Chemistry, School of Mathematics and Natural Sciences, University of Wuppertal, Gaussstrasse 20, Wuppertal, 42119, Germany.

Nadja KampschulteFood Chemistry, School of Mathematics and Natural Sciences, University of Wuppertal, Gaussstrasse 20, Wuppertal, 42119, Germany.

Kathrin PlitzkoFood Chemistry, School of Mathematics and Natural Sciences, University of Wuppertal, Gaussstrasse 20, Wuppertal, 42119, Germany.

Katja MoselFood Chemistry, School of Mathematics and Natural Sciences, University of Wuppertal, Gaussstrasse 20, Wuppertal, 42119, Germany.

Christophe MorisseauDepartment of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CA, 95616, USA.

Nils Helge SchebbFood Chemistry, School of Mathematics and Natural Sciences, University of Wuppertal, Gaussstrasse 20, Wuppertal, 42119, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Linoleic acid-derived epoxy-fatty acids (EpOMEs) are found in oxidized plant oils and processed foods. Consumption of oxidized oils may lead to a variety of negative health effects. Due to the assumed chemical reactivity of the epoxy-group, toxicity of epoxy-fatty acids, such as 9(10)-EpOME and 12(13)-EpOME, is frequently discussed. Therefore, we investigated the effect of 9(10)-EpOME and 12(13)-EpOME on cell viability by evaluating cell proliferation, LDH leakage, lysosomal integrity and dehydrogenase activity in HepG2 and Caco2 cells. Both tested epoxy-fatty acids show no or low cytotoxicity only above 50 μM in both cell lines, with 12(13)-EpOME being slightly more cytotoxic. This concentration is well above endogenous levels of EpOMEs in circulation.

Indexed as

Caco2 cellsEpOMEHepG2 cellsOxidized fatsOxidized oilsOxylipins

Identifiers

PMID42094293

DOI10.1016/j.bbrep.2026.102607

PMCPMC13139969

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.