Evidence map›Paper›PMID 42094247›Full record

ArticleAnnals of intensive care2026

CytoSorb haemoadsorption in critically ill children: a multicentre observational study on feasibility, safety, and outcomes, the CYTOPED study.

Gabriella Bottari, Stefania Bianzina, Anna Tessari, Monica Fae, Sara Giovannini, Stefano Scollo, Elena Caporossi, Fabio Paglialonga, Pietro Lonardi, Raffaella Sagredini and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of intensive care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Novel extracorporeal therapies in children.Pediatric nephrology (Berlin, Germany) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Gabriella BottariPediatric Intensive Care Unit, Children Hospital Bambino Gesù, IRCSS, Rome, Italy.
Stefania BianzinaNeonatal and Pediatric Intensive Care Unit, Department of Emergency Medicine, Anesthesia, and Critical Care, IRCSS, Istituto Giannina Gaslini, Genova, Italy.
Anna TessariPediatric Intensive Care Unit, Department of Woman's and Child's Health, University of Padova, Padova, Italy.
Monica FaeUniversity Hospital of Bologna, General and Pediatric Anesthesia and Intensive Care Department, Bologna, Italy.
Sara GiovanniniCardio-Thoracic and Vascular Anesthesia and Intensive Care Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy.
Stefano ScolloDepatment of Critical Care Medicine, The Hospital for Sick Children, Toronto, Canada.
Elena CaporossiDepartment of Cardiothoracic and Vascular Intensive Care, University Hospital Integrated Trust of Verona, Italy.
Fabio PaglialongaPediatric Nephrology and Dialysis Unit, University of Milan, Italy.
Pietro LonardiPediatric Nephrology Unit Regina Margherita Children's Hospital Torino, Italy.
Raffaella SagrediniChildren Hospital Burlo Garofalo, Pediatric Intensive Care Unit, Trieste, Italy.
Alessandro SimoniniPediatric Anesthesia and Intensive Care Unit, Salesi Children's Hospital, Ancona, Italy.
Fabio CaramelliUniversity Hospital of Bologna, General and Pediatric Anesthesia and Intensive Care Department, Bologna, Italy.
Germana LongoDialysis Unit, Bambino Gesù Children Hospital, IRCSS, Rome, Italy.
Corrado CecchettiPediatric Intensive Care Unit, Children Hospital Bambino Gesù, IRCSS, Rome, Italy.
Andrea MoscatelliNeonatal and Pediatric Intensive Care Unit, Department of Emergency Medicine, Anesthesia, and Critical Care, IRCSS, Istituto Giannina Gaslini, Genova, Italy.
Isabella GuzzoPediatric Intensive Care Unit, Children Hospital Bambino Gesù, IRCSS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: CytoSorb® is a cartridge for the adsorption of inflammatory mediators, bilirubin, myoglobin and other xenobiotics, directly from the blood stream. Clinical experience is widely documented in adults, whereas, in the paediatric settings, it is currently limited to single case reports or monocentric studies. In order to be able to collect evidence in larger paediatric populations, an Italian multicentre network (CYTOPED study group) was founded. Methods: Italian multicentric observational registry on the use of CytoSorb® in critically ill paediatric patients. Prospective enrolment by Italian Children's Hospitals has been ongoing since February 2021 with a retrospective analysis conducted from February 2018 to February 2021. Results: 62 patients have been enrolled. Median Paediatric Logistic Organ Dysfunction 2 (PELOD-2) score on Paediatric Intensive Care Unit (PICU) admission was 7 (IQR 4;10). The primary clinical indications for haemoadsorption (HA) were sepsis or septic shock ( Conclusion: Our data provide some insights into safety and feasibility of CytoSorb® therapy in children. The advancement of the study and the prospective arm of CYTOPED registry will allow further investigation into this therapy, including dosage, timing and use of antibiotics in conjunction with extracorporeal blood purification techniques.

Indexed as

Extra-corporeal therapiesHemadsorptionLiver failurePaediatric critical careRhabdomyolysisSeptic shock

Identifiers

PMID42094247
PMCPMC13141983

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.