ArticleERJ open research2026
Validation of bronchial airway gene expression associated with bronchiectasis in nasal epithelium.
Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Objectives: Examine the bronchial epithelium-derived gene expression signature of bronchiectasis (BE) in nasal epithelium. Methods: We studied 220 participants from the Detection of Early Lung Cancer Among Military Personnel study with bulk RNA sequencing of nasal epithelium brushings. Gene set enrichment analysis (GSEA) examined whether genes previously identified as increased or decreased in the bronchial epithelium of individuals with radiologic BE are enriched among genes most altered in nasal epithelium. GSEA and cell-type specific signatures assessed changes in nasal epithelium cellular composition associated with radiologic BE. Results: No genes were significantly differentially expressed in nasal epithelium between participants with and participants without widespread radiologic BE. However, genes previously found altered in bronchial epithelium are concordantly enriched among genes most increased or decreased in nasal epithelium (p=3×10 Conclusion: This work validates our bronchial BE signature in an independent dataset and demonstrates that gene expression changes associated with radiologic BE in nasal epithelium are concordant but reduced in magnitude compared with bronchial epithelium. These findings support considering nasal brushings as a less invasive tool for BE screening and monitoring.
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