Evidence map›Paper›PMID 42094136›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Epigenetic inflammation signatures and lung cancer risk among never-smoking women: a nested case-control study.

Mohammad L Rahman, Aishani Gargapati, Lauren M Hurwitz, Wei Hu, Alexander P Keil, Charles E Breeze, Anil Chaturvedi, Jianxin Shi, Qiuyin Cai, Gong Yang and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Mohammad L RahmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0001-8322-0495
Aishani GargapatiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Lauren M HurwitzDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Wei HuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Alexander P KeilDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Charles E BreezeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Anil ChaturvediDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Jianxin ShiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA.
Gong YangDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA.
Yu-Tang GaoShanghai Cancer Institute, Shanghai, China.
David C ChristianiDepartmemnt of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA.
Jason Y Y WongEpidemiology and Community Health Branch, National Heart Lung and Blood Institute, Bethesda, MD, USA.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Funding

The Boston Lung Cancer Survival CohortU01CA209414 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI David C Christiani · 2017 to 2026
$12.2M
Shanghai Men's Health StudyUM1CA173640 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHU, XIAO-OU · 2013 to 2017
$4.9M
CANCER RISK REDUCTION AND DIET--A COHORT STUDY OF WOMENR01CA070867 · NCI · VANDERBILT UNIVERSITY · PI ZHENG, WEI · 1996 to 2007
$4.6M
NCI NIH HHS R01 CA070867NCI NIH HHS U01 CA209414NCI NIH HHS UM1 CA173640
6 · The paper itself

Abstract

Introduction: Chronic inflammation has been implicated in lung carcinogenesis. Prospective studies have linked higher circulating C-reactive protein (CRP), an acute-phase inflammation marker, to higher lung cancer risk in predominantly smoking populations but lower risk in never smokers. We evaluated DNA methylation-based inflammation risk scores (DNAm-IRSs), which may capture longer-term immune-inflammatory and exposure-related biology, with lung cancer risk among never smokers. Methods: We evaluated six DNAm-IRSs, including four CRP-based scores (IRS Results: Circulating CRP correlated positively with IRS Conclusions: Among never smokers, selected CRP-related DNAm-IRSs were associated with lower lung cancer risk and were linked to immune features consistent with antitumor activity.

Indexed as

C-reactive protein (CRP)DNA methylationInflammation risk score (IRS)Lung cancerNever-smokers

Identifiers

PMID42094136
PMCPMC13142569

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.