Evidence map›Paper›PMID 42094128›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Neuron-Enriched Extracellular Vesicle MicroRNAs Reflect Hormone-Sensitive Neural Pathway Changes from Early to Late Perimenopause.

Rebekah L Frye, Dana M Lapato, Christopher Sikes-Keilp, JoAnn V Pinkerton, Jennifer L Payne, Vasily Yakovlev, Roxann Roberson-Nay

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rebekah L FryeUniversity of Virginia, School of Medicine, Neuroscience Graduate Program, Charlottesville, VA.ORCID 0009-0000-4269-7764
Dana M LapatoVirginia Commonwealth University, School of Medicine, Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA.ORCID 0000-0001-8169-9754
Christopher Sikes-KeilpUniversity of North Carolina, School of Medicine, Department of Psychiatry, Chapel Hill, NC.ORCID 0000-0002-4337-1229
JoAnn V PinkertonUniversity of Virginia, School of Medicine, Department of Obstetrics and Gynecology, Charlottesville, VA.ORCID 0000-0001-6707-3405
Jennifer L PayneUniversity of Virginia, School of Medicine, Department of Psychiatry and Neurobehavioral Sciences, Charlottesville, VA.ORCID 0000-0003-0006-1199
Vasily YakovlevVirginia Commonwealth University, School of Medicine, Department of Radiation Oncology, Richmond, VA.ORCID 0000-0002-1298-0232
Roxann Roberson-NayUniversity of Virginia, School of Medicine, Department of Psychiatry and Neurobehavioral Sciences, Charlottesville, VA.ORCID 0000-0002-1037-3121

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The menopausal transition represents a major neuroendocrine shift marked by declining estradiol and progesterone, rising follicle-stimulating hormone, and increased vulnerability to cognitive and affective symptoms. Despite extensive evidence of hormone-related neural changes, few biomarkers directly index hormone-sensitive neuronal adaptations

Identifiers

PMID42094128
PMCPMC13142559

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.