ArticleVeterinary and animal science2026
The non-monotonic dose-effect of resveratrol on testicular steroidogenesis in male arctic foxes (Vulpes lagopus): Mechanisms revealed by integrated transcriptomic and metabolomic analyses.
Article in Veterinary and animal science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The Arctic fox is a mammal that is intensively farmed for its valuable fur, and its farming industry has developed on a large scale worldwide. However, the current farming of arctic foxes still faces challenges such as reproductive efficiency, which hinder the sustainable development of the industry. Resveratrol is a natural polyphenolic compound found in plants such as grapes and Japanese knotweed. It has attracted significant attention due to its potent antioxidant and anti-inflammatory properties and has been shown to have reproductive protective effects in mammals by regulating the steroid hormone synthesis pathway. In this experiment, 40 foxes were divided into four groups and fed diets containing 0, 10, 50, or 100 mg/kg of resveratrol for two months. The results showed that serum testosterone and luteinizing hormone levels exhibited a non-monotonic dose-response relationship, peaking in the 50 mg/kg group. Integrated transcriptomic and metabolomic analyses indicated that low doses may have no significant effect due to insufficient pathway activation, medium doses likely promote testosterone synthesis by upregulating key steroidogenic genes such as
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