ArticleResearch square2026
Pathogenic CD8+ T cells target K71+ Henle's layer by forming cytolytic immune synapses in Alopecia Areata.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
CD8+ NKG2D+ T cells mediate hair follicle (HF) damage in Alopecia Areata (AA); however, the mechanisms and targets of T cell attack are not yet known. Here, we showed that CD8+ T cells penetrate the dermal sheath and epithelial layers of HF in AA and stop abruptly upon reaching Henle's layer of the inner root sheath. CD8+ T cells assembled a cytolytic immune synapse (IS) with polarization of Lck kinase and convergence of granzyme B. The formation of IS and localization of caspase-8-dependent apoptosis in KRT71+ Henle's layer of IRS pinpointed these cells as T cell targets in AA. Using direct visualization of
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