Evidence map›Paper›PMID 42094023›Full record

ArticleBMJ oncology2026

Temporal trends in behavioural risk factors for cancers with rising incidence in younger adults: an analysis of population-based data in England.

Montserrat Garcia-Closas, Zoey Richards, Reuben Frost, Marc J Gunter, Amy Berrington de Gonzalez

Abstract read
In one paragraph

Article in BMJ oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Montserrat Garcia-ClosasIntegrative Cancer Epidemiology, Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.ORCID https://orcid.org/0000-0003-1033-2650
Zoey Richards *Integrative Cancer Epidemiology, Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Reuben Frost *Integrative Cancer Epidemiology, Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Marc J GunterThe Cancer Epidemiology and Prevention Research Unit, Institute of Cancer Research and Imperial College London, London, UK.
Amy Berrington de GonzalezThe Cancer Epidemiology and Prevention Research Unit, Institute of Cancer Research and Imperial College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To assess whether changes in behavioural risk factors could explain rising cancer incidence in younger adults in England, and to evaluate the extent to which established and suspected risk factors contribute to these trends. Methods and analysis: Cancer incidence data from national registries (2001-2019) for 22 sites in women and 21 in men identified cancers with increasing incidence in adults aged 20-49 years. Trends in smoking, alcohol, diet, body mass index (BMI) and physical inactivity were examined using national health surveys. Annual percentage changes (APCs) quantified trends by age and sex. Population attributable fractions (PAFs) estimated the proportion of cancers attributable to risk factors and disaggregated attributable from non-attributable incidence rates. Results: Eleven cancer sites (three female-specific) with established behavioural risk factors showed rising incidence in younger adults. Similar trends were observed in older adults, except for colorectal and ovarian cancer, which increased only in younger adults. For some cancers, incidence increased more rapidly in younger than older adults. PAFs for younger adults ranged from 7% to 65% depending on cancer type. All risk factors except obesity showed stable or declining prevalence. For BMI-related cancers, both BMI-attributable and BMI-non-attributable incidence increased, though more slowly for the latter. For example, BMI-attributable colorectal cancer in younger women increased from 0.9 to 1.6 per 100 000 (APC 4.3%), while non-attributable rates rose from 6.4 to 9.6 (APC 3.2%). Conclusions: Behavioural risk factors account for a substantial share of cancer burden but, apart from BMI, are unlikely to explain the rising incidence in younger adults. The present findings underscore the urgent need to investigate emerging risk factors, while strengthening prevention efforts targeting known factors across all ages.

Indexed as

EpidemiologyMedical oncology

Identifiers

PMID42094023
PMCPMC13141096

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.