Evidence map›Paper›PMID 42093998›Full record

ArticleFrontiers in immunology2026

Loss of SHP-1 in CD11c

Miguel Galán, Elena Hernández-García, Pablo Munné, Ana Redondo-Urzainqui, Francisco J Cueto, Jon Sicilia, Sergio Callejas Alejano, M Ascensión Rey-Martín, Ana Dopazo, David Sancho and 1 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Miguel Galán *Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Elena Hernández-García *Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Pablo Munné *Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Ana Redondo-UrzainquiCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Francisco J CuetoCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Jon SiciliaCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Sergio Callejas AlejanoCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
M Ascensión Rey-MartínCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Ana DopazoCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
David Sancho *Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Salvador Iborra *Fundación Inmunotek, Alcalá de Henares, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Tyrosine kinases and phosphatases regulate protein phosphorylation and maintain cellular homeostasis. The phosphoprotein tyrosine phosphatase SHP-1 (encoded by the Methods: To dissect the specific role of SHP1 in CD11c Results: Tumor rejection was impaired when SHP-1 was depleted in CD11c Conclusions: These results show that SHP-1 depletion in CD11c

Indexed as

Dendritic CellsProtein Tyrosine Phosphatase, Non-Receptor Type 6AnimalsCD11c AntigenCell Line, TumorMacrophagesMiceMice, Inbred C57BLMice, KnockoutTumor MicroenvironmentCD11c AntigenProtein Tyrosine Phosphatase, Non-Receptor Type 6Ptpn6 protein, mouseCD8+ T cell responseconventional type 1 dendritic cellsmacrophagesSHP-1tumor rejection

Identifiers

PMID42093998
PMCPMC13139866

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.