ArticleFrontiers in immunology2026
Pollen-derived extracellular vesicles promotes allergic airway inflammation.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Asthma remains a global health burden, affecting over 300 million individuals worldwide, with its pathogenesis involving complex interactions between genetic predisposition and environmental allergens. Pollen is a well-established trigger of allergic asthma. However, the precise mechanisms underlying its allergenic activity remain incompletely understood. Recent advances have highlighted the emerging role of plant-derived extracellular vesicles in immune modulation. Notably, pollen-derived extracellular vesicles (PDEVs) have been identified as carriers of allergenic proteins. Therefore, this study investigates whether pollen contains extracellular vesicles(EVs) and whether these vesicles can induce allergic airway inflammation. Methods: We isolated extracellular vesicles from Results: PDEVs are nanoscale lipid bilayer structures containing diverse allergenic proteins and exhibiting structural stability. PDEVs induced significantly stronger pro-inflammatory responses compared to pollen supernatant (Sup) Conclusion: Our findings suggest extracellular vesicles present in pollen grains, which may represent a critical mechanism underlying pollen-induced airway inflammation. Targeting PDEVs may offer new therapeutic strategies for allergic airway diseases prevention and treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.