ArticleFrontiers in neurology
Utility of Ki-67 index combined with alpha-fetoprotein and lactate dehydrogenase in distinguishing mature from immature ovarian teratomas in children.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Accurate differentiation between mature and immature ovarian teratomas in children remains a diagnostic challenge. Current histopathological grading is subjective, and reliable preoperative biomarkers are lacking. This study aimed to evaluate the diagnostic and prognostic value of Ki-67, alpha-fetoprotein (AFP), and lactate dehydrogenase (LDH), individually and in combination. Methods: We retrospectively analyzed 82 pediatric patients (≤18 years) with histologically confirmed ovarian teratomas, including 45 mature and 37 immature cases. Serum AFP and LDH levels and Ki-67 proliferation indices were compared between groups. Multivariate logistic regression and receiver operating characteristic (ROC) analyses were performed to identify independent predictors and assess diagnostic performance. Recurrence-free survival (RFS) was evaluated using Kaplan-Meier and Cox regression analyses. Results: AFP, LDH, and Ki-67 levels were significantly higher in the immature group than in the mature group (all Conclusion: The combined assessment of Ki-67, AFP, and LDH provides a robust biomarker panel for differentiating immature from mature ovarian teratomas in children and predicting recurrence risk. Integration of proliferative and metabolic indicators into pathological evaluation may enhance diagnostic precision and support individualized management in pediatric ovarian germ cell tumors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.