ArticleOncoscience2026
Selective blood-brain barrier penetration and tumor targeting of nitrosylcobalamin in glioblastoma: Pharmacokinetics, tissue distribution, and synergistic activity with trail and temozolomide.
Article in Oncoscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundGlioblastoma multiforme (GBM) remains a lethal brain tumor characterized by poor response to chemotherapy and limited blood-brain barrier (BBB) permeability. Nitrosylcobalamin (NO-Cbl), a nitric oxide (NO)-releasing cobalamin analog, was developed to selectively deliver cytotoxic NO to tumors through the transcobalamin II receptor (CD320).
methodsNO-Cbl was evaluated across the NCI-60 tumor panel, followed by pharmacokinetic and biodistribution studies in glioblastoma-bearing rats using nitrate and cobalamin quantification in tissues, serum, and cerebrospinal fluid (CSF). Synergistic activity with TRAIL or temozolomide was assessed in human U87 and D54 glioma cells using SRB assays and Chou-Talalay analysis.
resultsNO-Cbl showed broad antitumor activity
conclusionThis pilot study demonstrates that NO-Cbl crosses the BBB, accumulates selectively in brain tumor tissue, and synergizes with established and experimental glioblastoma therapies. These findings establish a translational foundation for developing cobalamin-based therapeutics as a novel treatment strategy for glioblastoma.
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