ArticleFrontiers in pharmacology2026
A novel quinine derivative as a PIM-1 kinase inhibitor induces apoptosis via mitochondrial depolarization with selective cytotoxicity in acute lymphoblastic leukemia cells.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Acute lymphoblastic leukemia (ALL) remains a major therapeutic challenge, particularly in adult patients with poor tolerance to intensive chemotherapy, underscoring the need for novel and selective antileukemic agents that target more specific pharmacological targets and contribute to the development of new, less invasive therapeutic interventions. Quinine, a natural alkaloid, and its derivatives have demonstrated promising anticancer properties that could contribute to this development. Purpose: In this study, a series of lipophilic and amphiphilic quinine derivatives were synthesized and structurally characterized, and the Results and discussion: Among the 26 synthesized compounds, compound Conclusion: Overall, these findings identify compound
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