Evidence map›Paper›PMID 42093833›Full record

ArticleBMJ neurology open2026

Associations of chrononutrition and sleep with fatigue in multiple sclerosis: an analysis of the Swiss Multiple Sclerosis Registry.

Nicholas E Phillips, Vladeta Ajdacic-Gross, Jessica Rebeaud, Guillaume Thévoz, Stefania Iaquinto, Claudia Baum, Christian P Kamm, Jens Kuhle, Irene Rapold, Patrick Roth and 6 more

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Article in BMJ neurology open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nicholas E PhillipsService of Endocrinology, Diabetology and Metabolism, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Vladeta Ajdacic-GrossSwiss MS Registry, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zürich, Switzerland.
Jessica RebeaudLaboratories of Neuroimmunology, Center for Research in Neuroscience and Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Guillaume ThévozLaboratories of Neuroimmunology, Center for Research in Neuroscience and Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Stefania IaquintoDepartment of Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zürich, Zürich, Switzerland.
Claudia BaumNeurology, Rehabilitation Hospital Zihlschlacht, Zihlschlacht-Sitterdorf, Switzerland.ORCID https://orcid.org/0009-0002-0656-4854
Christian P KammNeurology and Neurorehabilitation Center, Lucerne Cantonal Hospital, Lucerne, Switzerland.
Jens KuhleDepartments of Biomedicine and Clinical Research, Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0002-6963-8892
Irene RapoldDepartment of Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zürich, Zürich, Switzerland.
Patrick RothDepartment of Neurology, University Hospital Zürich and University of Zürich, Zürich, Switzerland.
Chiara ZeccaDepartment of Neurology, Neurocenter of Southern Switzerland, Lugano Regional Hospital, Lugano, Switzerland.
Viktor von WylDepartment of Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zürich, Zürich, Switzerland.
Simone Jpm EussenDepartment of Epidemiology; Cardiovascular Research Institute Maastricht (CARIM); and Care and Public Health Research Institute (CAPHRI), Maastricht University Faculty of Health Medicine and Life Sciences, Maastricht, Netherlands.
Nina SteinemannSwiss MS Registry, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zürich, Switzerland.
Caroline Pot *Laboratories of Neuroimmunology, Center for Research in Neuroscience and Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Tinh-Hai Collet *Service of Endocrinology, Diabetology and Metabolism, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland.ORCID https://orcid.org/0000-0002-3243-1222

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Fatigue is a common symptom of multiple sclerosis (MS) and impacts quality of life, yet the role of chrononutrition and sleep in MS management remains underexplored. We aimed to investigate the cross-sectional associations of meal and sleep timing with fatigue in persons with MS (pwMS). Methods: We implemented a chrononutrition questionnaire within the Swiss MS Registry to quantify the relationships between meal timing, sleep patterns and fatigue among pwMS. Results: In unadjusted analyses of 958 participants (median age 49 years, 73% women), a longer interval between the first and last meals (eating window) was associated with less fatigue (OR per 1 SD change in predictor=0.84, 95% CI 0.75 to 0.94), while later wake-up (OR 1.26, 95% CI 1.12 to 1.43) and first meal (OR 1.28, 95% CI 1.14 to 1.44) were associated with more fatigue. Later weekend versus weekday patterns ('social jetlag') across meal and sleep timing were associated with less fatigue.Adjustment for lifestyle factors attenuated most of the relationships, with employment status being the most influential. After adjustment, a larger 'social jetlag' in first meal (OR 0.86, 95% CI 0.76 to 0.97) and going to bed later (OR 0.86, 95% CI 0.76 to 0.97) remained associated with less fatigue, while a longer time in bed (OR 1.28, 95% CI 1.12 to 1.46) remained associated with more fatigue. Conclusions: Associations of meal and sleep timing with fatigue in pwMS were influenced by lifestyle factors, particularly employment status. After adjustment, eating the first meal later during weekends compared with weekdays, going to bed later and a shorter time in bed were associated with less reported fatigue. The apparent benefits of 'social jetlag' on first meal times require confirmation from prospective and interventional studies.

Indexed as

MULTIPLE SCLEROSISSLEEP

Identifiers

PMID42093833
PMCPMC13141214

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.