In-line fluorescence characterization of sodium fluorescein and application as tracer in residence time distribution analysis at elevated temperatures.

Dominik Hug, Jonas Meury, Joseph Dumpler, Corina Sägesser, Alexander Mathys

Abstract read

In one paragraph

Article in MethodsX, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Dominik HugSustainable Food Processing Laboratory, Department of Health Science and Technology, ETH Zurich 8092 Zurich, Switzerland.

Jonas MeurySustainable Food Processing Laboratory, Department of Health Science and Technology, ETH Zurich 8092 Zurich, Switzerland.

Joseph DumplerSustainable Food Processing Laboratory, Department of Health Science and Technology, ETH Zurich 8092 Zurich, Switzerland.

Corina SägesserSustainable Food Processing Laboratory, Department of Health Science and Technology, ETH Zurich 8092 Zurich, Switzerland.

Alexander MathysSustainable Food Processing Laboratory, Department of Health Science and Technology, ETH Zurich 8092 Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Residence time distribution (RTD) characterization to validate continuous thermal processing systems at elevated temperatures is an important metric and particularly relevant for ultra-high temperature (UHT) and high-temperature short-time (HTST) treatments. Sodium fluorescein (SF) was investigated as a fluorescent tracer for RTD measurements at temperatures extending beyond previously reported ranges. Using a custom-built flow-through measurement system, fluorescence intensity and emission spectra were recorded from 65 - 136 °C in a stabilized pH 7.4 phosphate buffer. Linear thermal quenching (

Indexed as

Continuous thermal processingFluorescence spectroscopyFluorescent tracerResidence time distributionSodium fluoresceinTracer characterization

Identifiers

PMID42093814

DOI10.1016/j.mex.2026.103925

PMCPMC13141772

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.