Evidence map›Paper›PMID 42093740›Full record

ArticleMaterials today. Bio2026

Edaravone delivery of exosome-liposome hybrid nanoparticles for the treatment of ischemic stroke.

Zhihan Zhu, Guilong Zhang, Xiang Li, Qiankun Zhang, Wei Wang, Guojian Wu, Waqas Ahmed, Chen Wang, Aimei Zhao, Dongshan Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhihan ZhuDepartment of Neurosurgery, Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou, Guangdong Province, China.
Guilong ZhangDepartment of Neurosurgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China.
Xiang LiDepartment of Urology, The Second Affiliated Hospital of The Chinese University of Hong Kong/Longgang District People's Hospital of Shenzhen, Shenzhen, Guangdong Province, China.
Qiankun ZhangDepartment of Neurosurgery, Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou, Guangdong Province, China.
Wei WangDepartment of Neurosurgery, Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou, Guangdong Province, China.
Guojian WuSchool of Medicine, Southeast University, Nanjing, Jiangsu Province, China.
Waqas AhmedSchool of Medicine, Southeast University, Nanjing, Jiangsu Province, China.
Chen WangDepartment of Neurosurgery, Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou, Guangdong Province, China.
Aimei ZhaoDepartment of Neurosurgery, Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou, Guangdong Province, China.
Dongshan ZhangDepartment of Neurosurgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China.
Tianran ChaiDepartment of Neurosurgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China.
Lanjie LeiKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang Province, China.
Lukui ChenDepartment of Neurosurgery, Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou, Guangdong Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke (IS) triggers neuroinflammatory cascades mediated by microglial polarization, where pro-inflammatory M1 phenotypes exacerbate neuronal damage, and anti-inflammatory M2 phenotypes promote repair. Edaravone (Eda), a free radical scavenger, shows potential for modulating microglial polarization but faces challenges in penetrating the blood-brain barrier (BBB) and achieving targeted delivery. This study develops a hybrid nanoparticle (SHp-NSCsome) that integrates hypoxia-preconditioned neural stem cell-derived exosomes with Eda-loaded liposomes functionalized with the ischemic-homing peptide SHp. SHp-NSCsome combines the biocompatibility and immunomodulatory properties of exosomes with the drug-loading capacity of liposomes, enabling efficient BBB traversal and targeting of ischemic lesions.

Indexed as

EdaravoneExosomeLiposomeMicrogliaNeural stem cellNeuroinflammationPolarization

Identifiers

PMID42093740
PMCPMC13141791

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.